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Home > Full-time facultyAssoc. Prof.  Hui-Min Su

ENGLISH INTRO

Su, Hui-Min
Ph.D., Cornell
Associate Professor
Phone:+886-2-23123456-ext 88248
E-mail:
hmsu1203@ntu.edu.tw

 


 

Research Experiences & Education:
2001-2010 Assistant Professor, Physiology, College of      
                    Medicine, National Taiwan University
1998-2001 Research Associate, Neurogenetics Research
                    Center, Kennedy Krieger Institute, Neurology,
                    School of Medicine, Johns Hopkins University
1998  Ph. D. Nutritional Sciences, Cornell University
1995  M.S.   Nutritional Sciences, Cornell University
1990  B.S.   Agriculture Chemistry, National Taiwan University
 
Research area:
 
Our research area has been focusing on the fatty acids and estrogen on breast cancer and Alzheimer’s disease (AD). The goal is to identify a nature supplementation, fish oil enriched in docosahexaenoic acid (DHA, 22:6n-3) on the prevention of both Alzheimer’s disease and breast cancer. We hypothesized that timing, but not the duration, of n-3 fatty acids supplementation is critical for reducing both breast cancer risk and age-related memory decline, and that n-3 fatty acids supplementation during gestation and lactation would have a greater benefit on the prevention of both diseases. 
Currently, we study the mechanism of n-6 and n-3 fatty acids on nongenomic estrogen receptor a signaling and nuclear factor kappaB activation in drug-resistant human breast cancer cell line MCF-7. We will extend our study to evaluate whether a maternal n-3 fatty acid-deficient diet during pregnancy and lactation regulates the hypothalamic-pituitary-adrenal (HPA) axis response, regulation, and epigenetic changes leading to anxiety- and depression-like behaviors in postpartum rats and in the offspring later in life.

  

 Publications 

 

  1. Chen HF (陳鏏仹) and Su HM* (2012) Exposure to a maternal n-3 fatty acid-deficient diet during brain development provokes excessive hypothalamic-pituitary-adrenal axis responses to stress and behavioral indices of depression and anxiety in male rat offspring later in life. Journal of Nutritional Biochemistry, (accepted)
  2. Chen HF (陳鏏仹) and Su HM* (2012) Fish oil supplementation of maternal rats on an n-3 fatty acid-deficient diet prevents depletion of maternal brain regional docosahexaenoic acid levels and has a postpartum anxiolytic effect. Journal of Nutritional Biochemistry, (In press)
  3. Su HM*, Hsieh PH(謝佩璇), and Chen HF (2010) A maternal high n-6 fat diet with fish oil supplementation during pregnancy and lactation in rats decreases breast cancer risk in the female offspring. Journal of Nutritional Biochemistry, 21:1033-1037
  4. Su HM* (2010) Mechanisms of n-3 fatty acid-mediated development and maintenance of learning memory performance. Journal of Nutritional Biochemistry, 21:364-373
  5. Lu IF(呂怡芬), Hasio AC, Hu MC, Yang FM and Su HM* (2010) Docosahexaenoic acid induces proteasome-dependent degradation of estrogen receptor a and inhibits the downstream signaling target in MCF-7 breast cancer cells. Journal of Nutritional Biochemistry, 21:512-517.
  6. Wang PY(王寶源), Chen JJ, and Su HM* (2010)Docosahexaenoic acid supplementation of primary rat hippocampal neurons attenuates the neurotoxicity induced by aggregated amyloid beta protein42 and upregulates cytoskeletal protein expression. Journal of Nutritional Biochemistry, 21:345-350.
  7. Lo CY (駱中郁), Hsieh PH, Chen HF and Su HM* (2009) Maternal high fat diet during pregnancy in rats results in a greater risk of carcinogen-induced mammary tumors in female offspring than high fat intake in postnatal life.International Journal of Cancer, 125:767-773.
  8. Chung WL(鍾宛伶), Chen JJ, and Su HM* (2008) Fish oil supplementation of control and (n-3) fatty acid-deficient male rats enhances reference and working memory performance and increases brain regional docosahexaenoic acid levels. Journal of Nutrition. 138:1165-1171.
  9. Hasio AC(蕭安哲), Chen JJ, Chung WL and Su HM*. (2008) Effect of Brain DHA levels on cytoskeleton expression. Asia Pacific Journal of Clinical Nutrition, 17:158-161.
  10. Su HM*, Faust PL, Moser AB, Moser HW, Watkins PA. (2003) Docosahexaenoic acid synthesis and transport in peroxisomal disorders studied in vivo & in vitro. In book of Essential Fatty Acids and Eicosanoids: Invited papers from the Fifth International Congress. American Oil Chemistry Society.
  11. Su HM*, Moser AB, Moser HW, Watkins PA. (2001) Peroxisomal straight-chain acyl-coA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesis. Journal of Biological Chemistry. 276:38115-20.
  12. Faust PL, Su HM, Moser A, Moser HW.(2001) The peroxisome deficient PEX2 Zellweger mouse: pathologic and biochemical correlates of lipid dysfunction. Journal of Molecular Neuroscience. 16:289-97
  13. Su HM, Huang MC, Saad NM, Nathanielsz PW, Brenna JT. (2001) Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study. Journal of Lipid Research. 42:581-6.
  14. Su HM, Corso TN, Nathanielsz PW, Brenna JT. (1999) Linoleic acid kinetics and conversion to arachidonic acid in the pregnant and fetal baboon. Journal of Lipid Research. 40:1304-12.
  15. Su HM, Bernardo L, Mirmiran M, Ma XH, Corso TN, Nathanielsz PW, Brenna JT. (1999) Bioequivalence of dietary alpha-linolenic and docosahexaenoic acids as sources of docosahexaenoate accretion in brain and associated organs of neonatal baboons. Pediatric Research. 45:87-93.
  16. Su HM, Bernardo L, Mirmiran M, Ma XH, Nathanielsz PW, Brenna JT. (1999) Dietary 18:3n-3 and 22:6n-3 as sources of 22:6n-3 accretion in neonatal baboon brain and associated organs. Lipids. 34:S347-50.
  17. Su HM, Brenna JT.(1998) Simultaneous measurement of desaturase activities using stable isotope tracers or a nontracer method. Analytical Biochemistry. 261:43-50.
  18. Su HM, Keswick LA, Brenna JT. (1996) Increasing dietary linoleic acid in young rats increases and then decreases docosahexaenoic acid in retina but not in brain. Lipids. 31:1289-98.
  19. Sheaff RC, Su HM, Keswick LA, Brenna JT. (1995) Conversion of alpha-linolenate to docosahexaenoate is not depressed by high dietary levels of linoleate in young rats: tracer evidence using high precision mass spectrometry. Journal of Lipid Research. 36:998-1008.