未命名 1
回首頁 > 生理所主任湯志永教授兼主任

學術著作

Publication List:

  • Fu, S.-J., Jeng, C.-J., Ma, C.-H., Peng, Y.-J., Lee, C.-M., Fang, Y.-C., Lee, Y.-C., Tang, S.-C., Hu, M.-C., and Tang, C.-Y. (2017) Ubiquitin ligase RNF138 promotes episodic ataxia type 2-associated aberrant degradation of human Cav2.1 (P/Q-type) calcium channels. J. Neurosci. 37:2485-2503.

  • Hsu, P.-H., Ma, Y.-T., Fang, Y.-C., Huang, J.-J., Gan, Y.-L., Chang, P.-T., Jow, G.-M., Tang, C.-Y.*, and Jeng, C.-J.* (2017) Cullin 7 mediates proteasomal and lysosomal degradations of rat Eag1 potassium channels. Sci. Rep. 7, 40825; doi: 10.1038/srep40825.

  • Peng, Y.-J., Huang, J.-J., Wu, H.-H., Hsieh, H.-Y., Wu, C.-Y., Chen, S.-C., Chen, T.-Y., and Tang, C.-Y. (2016) Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β. Sci. Rep. 6, 32444; doi: 10.1038/srep32444.

  • Chen, S.-H., Fu, S.-J., Huang, J.-J., and Tang, C.-Y. (2016) The episodic ataxia type 1 mutation I262T alters voltage-dependent gating and disrupts protein biosynthesis of human Kv1.1 potassium channels. Sci. Rep. 6, 19378; doi: 10.1038/srep19378.

  • Chen, Y.-A., Peng, Y.-J., Hu, M.-C., Huang, J.-J., Chien, Y.-C., Wu, J.-T., Chen, T.-Y., and Tang, C.-Y. (2015) The cullin 4A/B-DDB1-cereblon E3 ubiquitin ligase complex mediates the degradation of CLC-1 chloride channels. Sci. Rep. 5, 10667; doi: 10.1038/srep10667.

  • Liu, D.-C., Jow, G.-M. Chuang, C.-C., Peng, Y.-J., Hsu, P.-H., and Tang, C.-Y. (2013) Densin-180 is not a transmembrane protein. Cell Biochem. Biophysic. 67:773-783.

  • Lee, T.-T., Zhang, X.-D. Chuang, C.-C., Chen, J.-J., Chen, Y.-A., Chen, S.-C., Chen, T.-Y., and Tang, C.-Y. (2013) Myotonia congenita mutation enhances the degradation of human CLC-1 chloride channels. PLoS One 8(2):e55930.

  • Richman, D.P., Yu, Y., Lee, T.-T., Tseng, P.-Y., Yu, W.-P., Maselli, R.A., Tang, C.-Y. and Chen, T.-Y. (2012) Dominantly inherited myotonia congenita resulting from a mutation that increases open probability of the muscle chloride channel CLC-1. Neuromol Med 14: 328-337.

  • Yi, Y.-H., Chang, Y.-S., Lin, C.-H., Lew, T.-S., Tang, C.-Y., Tseng, W.-L, Tseng, C.-P., and Lo, S.J. (2012) Integrin-mediated membrane blebbing is dependent on sodium-proton exchanger 1 and sodium-calcium exchanger 1 activity. J Biol Chem 287:10316-10324.
  • Tang, C.-Y. and Chen, T.Y. (2011) Physiology and pathophysiology of CLC-1: mechanisms of a chloride channel disease, myotonia. J. Biomed. Biotech. 685328.
  • Lai, Y.-P., Lin, C.-C., Liao, W.-L., Tang, C.-Y., Chen, S.-C. (2009) CD4+ T cell-derived IL-2 signals during early priming advances primary CD8+ T cell responses. PLoS ONE 4(11): e7766.
  • Lin, H.-M., Liu, C.-Y., Jow, G.-M., and Tang, C.-Y. (2009) Toluene disrupts synaptogenesis in cultured hippocampal neurons. Toxicol Lett 184:90–96.
  • Yi, Y.-H., Ho, P.-Y., Chen, T.-W., Lin, W.-J., Gukassyan, V., Tsai, T.-H., Wang, D.-W., Lew, T.-S., Tang, C.-Y., Lo, S. J., Chen, T.-Y., Kao, F.-J., and Lin, C.-H. (2009) Membrane targeting and coupling of NHE1/integrinαIIbβ3/NCX1 by lipid rafts following integrin-ligand interactions trigger Ca2+ oscillations. J Biol Chem 284:3855-3864.
  • Kung, F.-L., Tsai, J.-L., Lee, C.-H., Lou, K.-L., Tang, C.-Y., Liou, H.-H., Lu, K.-L., Chen, Y.-H., Wang, W.-J, and Tsai, M.-C. (2008) Effects of sodium azide, barium ion, d-amphetamine and procaine on inward rectifying potassium channel 6.2 expressed in Xenopus oocytes. J Formos Med Assoc 107:600–608.
  • Jeng, C.-J., Sun, M.-C., Chen, Y.-W., and Tang, C.-Y. (2008) Dominant-negative effects of episodic ataxia type 2 mutations involve disruption of membrane trafficking of human P/Q-type Ca2+ channels. J Cell Physiol 214:422-433.
  • Tsai, M.-C., Tang, C.-Y., Chang, Y.-T.,Cheng, C.-L., Liao, J.-M., Lee, S.-D., Pan, S.-F., Chen, M.-J., Huang, P.-C., Lin, T.-B. (2006) Effects of selective unilateral dorsal root(s) rhizotomy on micturition reflex in anesthetized rats. Neurourology and Urodynamics. 25:820-827.
  • Jeng, C.-J., Chen, Y.-T., Chen, Y.-W., and Tang, C.-Y. (2006) Dominant-negative Effects of human P/Q-type Ca2+ channel mutations associated with episodic ataxia type 2. Amer J Physiol-Cell Physiol 290:C1209-C1220.
  • Yeh, J.-H., Jeng, C.-J., Chen, Y.-W., Lin, H.-M., Wu, Y.-S., and Tang, C.-Y. (2005) Selective enhancement of tonic inhibitionby increasing ambient GABA is insufficient to suppress excitotoxicity in hippocampal neurons. Biochemical and Biophysical Research Communications 338:1417-1425.
  • Tang, C.-Y., Chen, Y.-W., Jow, G.-M., Chou, C.-J., and Jeng, C.-J. (2005) Beauvericin activates Ca2+-activated Cl- currents and induces cell deaths in Xenopus oocytes via influx of extracellular Ca2+. Chem Res Toxicol 18:825-833.
  • Jeng, C.-J., Chang, C.-C., and Tang, C.-Y. (2005) Differential localization of rat Eag1 and Eag2 K+ channels in hippocampal neuron. Neuroreport 16:229-233.
  • Stell, B.M., Brickley, S.G., Tang, C.-Y., Farrant, M., and Istvan Mody (2003) Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by δ subunit-containing GABAAreceptors. Proc. Natl. Acad. Sci. 100:14439-14444.
  • Lin, C.F., Liao, J.M., Tsai, S.J., Chiang, P.Y., Ting, H., Tang C.-Y., Lou, K.L., Hsieh, L.C., Wang, D.W., and Lin, T.B. (2003) Depressor effect on blood pressure and flow elicited by electroacupuncture in normal subjects. Auton Neurosci. 107:60-4.
  • Papazian, D.M., Silverman, W.R., Lin, M.C., Tiwari-Woodruff, S.K., and Tang, C.-Y. (2002) Structural organization of the voltage sensor in voltage-dependent potassium channels. Novartis Found Symp. 245:178-90
  • Silverman, W.R., Tang, C.-Y., Mock, A. F., Huh, S., and Papazian, D.M. (2000) Mg2+ modulates voltage-dependent activation in ether-à-go-go potassium channels by Binding between transmembrane segments S2 and S3. J. Gen. Physiol. 116:663-677.
  • Tang, C.-Y., Bezanilla, F., and Papazian, D.M. (2000) Extracellular Mg2+ modulates slow gating transitions and the opening of Drosophila ether-a-go-go K+ channels. J. Gen. Physiol. 115:319-337.
  • Tang, C.-Y., Schulteis, C.T., Jimenez, R.M., and Papazian, D.M. (1998) Shaker and eag K+ channel subunits fail to co-assemble in Xenopus oocytes.
    Biophys. J. 75:1263-1270.
  • Tang, C.-Y., and Papazian, D.M. (1997) Transfer of voltage independence from a rat olfactory channel to the Drosophila ether-a-go-go K+ channel. J. Gen. Physiol. 109:301-311.
  • Schulteis, C.T., John, S.A., Huang, Y., Tang, C.-Y., and Papazian, D.M. (1995) Conserved cysteine residues in the shaker K+ channel are not linked by a disulfide bond. Biochemistry 34: 1725-1733.