未命名 1
回首頁 > 生理所主任湯志永教授兼主任

English Intro

The research directions of my lab include

  1. Biophysics and cell biology of ion channels.
  2. Molecular mechanisms of channelopathies.
  3. Physiology and cell biology of synaptic networks in cultured neurons.

 

Publication List:

  • Fu, S.-J., Jeng, C.-J., Ma, C.-H., Peng, Y.-J., Lee, C.-M., Fang, Y.-C., Lee, Y.-C., Tang, S.-C., Hu, M.-C., and Tang, C.-Y. (2017) Ubiquitin ligase RNF138 promotes episodic ataxia type 2-associated aberrant degradation of human Cav2.1 (P/Q-type) calcium channels. J. Neurosci. 37:2485-2503.

  • Hsu, P.-H., Ma, Y.-T., Fang, Y.-C., Huang, J.-J., Gan, Y.-L., Chang, P.-T., Jow, G.-M., Tang, C.-Y.*, and Jeng, C.-J.* (2017) Cullin 7 mediates proteasomal and lysosomal degradations of rat Eag1 potassium channels. Sci. Rep. 7, 40825; doi: 10.1038/srep40825.

  • Peng, Y.-J., Huang, J.-J., Wu, H.-H., Hsieh, H.-Y., Wu, C.-Y., Chen, S.-C., Chen, T.-Y., and Tang, C.-Y. (2016) Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β. Sci. Rep. 6, 32444; doi: 10.1038/srep32444.

  • Chen, S.-H., Fu, S.-J., Huang, J.-J., and Tang, C.-Y. (2016) The episodic ataxia type 1 mutation I262T alters voltage-dependent gating and disrupts protein biosynthesis of human Kv1.1 potassium channels. Sci. Rep. 6, 19378; doi: 10.1038/srep19378.

  • Chen, Y.-A., Peng, Y.-J., Hu, M.-C., Huang, J.-J., Chien, Y.-C., Wu, J.-T., Chen, T.-Y., and Tang, C.-Y. (2015) The cullin 4A/B-DDB1-cereblon E3 ubiquitin ligase complex mediates the degradation of CLC-1 chloride channels. Sci. Rep. 5, 10667; doi: 10.1038/srep10667.

  • Liu, D.-C., Jow, G.-M. Chuang, C.-C., Peng, Y.-J., Hsu, P.-H., and Tang, C.-Y. (2013) Densin-180 is not a transmembrane protein. Cell Biochem. Biophysic. 67:773-783.

  • Lee, T.-T., Zhang, X.-D. Chuang, C.-C., Chen, J.-J., Chen, Y.-A., Chen, S.-C., Chen, T.-Y., and Tang, C.-Y. (2013) Myotonia congenita mutation enhances the degradation of human CLC-1 chloride channels. PLoS One 8(2):e55930.

  • Richman, D.P., Yu, Y., Lee, T.-T., Tseng, P.-Y., Yu, W.-P., Maselli, R.A., Tang, C.-Y. and Chen, T.-Y. (2012) Dominantly inherited myotonia congenita resulting from a mutation that increases open probability of the muscle chloride channel CLC-1. Neuromol Med 14:328-337.

  • Yi, Y.-H., Chang, Y.-S., Lin, C.-H., Lew, T.-S., Tang, C.-Y., Tseng, W.-L, Tseng, C.-P., and Lo, S.J. (2012) Integrin-mediated membrane blebbing is dependent on sodium-proton exchanger 1 and sodium-calcium exchanger 1 activity. J Biol Chem 287:10316-10324.

  • Tang, C.-Y. and Chen, T.Y. (2011) Physiology and pathophysiology of CLC-1: mechanisms of a chloride channel disease, myotonia. J. Biomed. Biotech. 685328.
  • Lai, Y.-P., Lin, C.-C., Liao, W.-L., Tang, C.-Y., Chen, S.-C. (2009) CD4+ T cell-derived IL-2 signals during early priming advances primary CD8+ T cell responses. PLoS ONE 4(11): e7766.
  • Lin, H.-M., Liu, C.-Y., Jow, G.-M., and Tang, C.-Y. (2009) Toluene disrupts synaptogenesis in cultured hippocampal neurons. Toxicol Lett 184:90–96.
  • Yi, Y.-H., Ho, P.-Y., Chen, T.-W., Lin, W.-J., Gukassyan, V., Tsai, T.-H., Wang, D.-W., Lew, T.-S., Tang, C.-Y., Lo, S. J., Chen, T.-Y., Kao, F.-J., and Lin, C.-H. (2009) Membrane targeting and coupling of NHE1/integrinαIIbβ3/NCX1 by lipid rafts following integrin-ligand interactions trigger Ca2+ oscillations. J Biol Chem 284:3855-3864.
  • Kung, F.-L., Tsai, J.-L., Lee, C.-H., Lou, K.-L., Tang, C.-Y., Liou, H.-H., Lu, K.-L., Chen, Y.-H., Wang, W.-J, and Tsai, M.-C. (2008) Effects of sodium azide, barium ion, d-amphetamine and procaine on inward rectifying potassium channel 6.2 expressed in Xenopus oocytes. J Formos Med Assoc 107:600–608.
  • Jeng, C.-J., Sun, M.-C., Chen, Y.-W., and Tang, C.-Y. (2008) Dominant-negative effects of episodic ataxia type 2 mutations involve disruption of membrane trafficking of human P/Q-type Ca2+ channels. J Cell Physiol 214:422-433.
  • Tsai, M.-C., Tang, C.-Y., Chang, Y.-T.,Cheng, C.-L., Liao, J.-M., Lee, S.-D., Pan, S.-F., Chen, M.-J., Huang, P.-C., Lin, T.-B. (2006) Effects of selective unilateral dorsal root(s) rhizotomy on micturition reflex in anesthetized rats. Neurourology and Urodynamics. 25:820-827.
  • Jeng, C.-J., Chen, Y.-T., Chen, Y.-W., and Tang, C.-Y. (2006) Dominant-negative Effects of human P/Q-type Ca2+ channel mutations associated with episodic ataxia type 2. Amer J Physiol-Cell Physiol 290:C1209-C1220.
  • Yeh, J.-H., Jeng, C.-J., Chen, Y.-W., Lin, H.-M., Wu, Y.-S., and Tang, C.-Y. (2005) Selective enhancement of tonic inhibitionby increasing ambient GABA is insufficient to suppress excitotoxicity in hippocampal neurons. Biochemical and Biophysical Research Communications 338:1417-1425.
  • Tang, C.-Y., Chen, Y.-W., Jow, G.-M., Chou, C.-J., and Jeng, C.-J. (2005) Beauvericin activates Ca2+-activated Cl- currents and induces cell deaths in Xenopus oocytes via influx of extracellular Ca2+. Chem Res Toxicol 18:825-833.
  • Jeng, C.-J., Chang, C.-C., and Tang, C.-Y. (2005) Differential localization of rat Eag1 and Eag2 K+ channels in hippocampal neuron. Neuroreport 16:229-233.
  • Stell, B.M., Brickley, S.G., Tang, C.-Y., Farrant, M., and Istvan Mody (2003) Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by δ subunit-containing GABAAreceptors. Proc. Natl. Acad. Sci. 100:14439-14444.
  • Lin, C.F., Liao, J.M., Tsai, S.J., Chiang, P.Y., Ting, H., Tang C.-Y., Lou, K.L., Hsieh, L.C., Wang, D.W., and Lin, T.B. (2003) Depressor effect on blood pressure and flow elicited by electroacupuncture in normal subjects. Auton Neurosci. 107:60-4.
  • Papazian, D.M., Silverman, W.R., Lin, M.C., Tiwari-Woodruff, S.K., and Tang, C.-Y. (2002) Structural organization of the voltage sensor in voltage-dependent potassium channels. Novartis Found Symp. 245:178-90
  • Silverman, W.R., Tang, C.-Y., Mock, A. F., Huh, S., and Papazian, D.M. (2000) Mg2+ modulates voltage-dependent activation in ether-à-go-go potassium channels by Binding between transmembrane segments S2 and S3. J. Gen. Physiol. 116:663-677.
  • Tang, C.-Y., Bezanilla, F., and Papazian, D.M. (2000) Extracellular Mg2+ modulates slow gating transitions and the opening of Drosophila ether-a-go-go K+ channels. J. Gen. Physiol. 115:319-337.
  • Tang, C.-Y., Schulteis, C.T., Jimenez, R.M., and Papazian, D.M. (1998) Shaker and eag K+ channel subunits fail to co-assemble in Xenopus oocytes.
    Biophys. J. 75:1263-1270.
  • Tang, C.-Y., and Papazian, D.M. (1997) Transfer of voltage independence from a rat olfactory channel to the Drosophila ether-a-go-go K+ channel. J. Gen. Physiol. 109:301-311.
  • Schulteis, C.T., John, S.A., Huang, Y., Tang, C.-Y., and Papazian, D.M. (1995) Conserved cysteine residues in the shaker K+ channel are not linked by a disulfide bond. Biochemistry 34: 1725-1733.