Prof. Kuo-Chu Chang

Kuo-Chu Chang was born in Taiwan in 1952. In 1991, he received his PhD degree from the Section of Biomedical Engineering, Institute of Electrical Engineering, National Taiwan University. He is now Professor in Physiology at the College of Medicine, National Taiwan University. His main research interests include the modeling of the systemic arterial tree and the systolic mechanical properties of the ventricular pump.

Publication Lists:

1. Chang RW, Chang CY, Wu MS, Yu HY, Luo JM, Chen YS, Lin FY, Lai LC, Wang CH*, Chang KC*. Systolic aortic pressure-time area is a useful index describing arterial wave properties in rats with diabetes. Scientific Reports | 5:17293 | DOI: 10.1038/srep17293.
2. Ko YH, Tsai MS, Chang RW, Chang CY, Wang CH, Wu MS, Liang JT, Chang KC*.(2015) Methylprednisolone protects cardiac pumping mechanics from deteriorating in lipopolysaccharide-treated rats. Front Physiol 6:348. doi: 10.3389/fphys.2015.00348.
3. Wang CH, Wu ET, Wu MS, Tsai MS, Ko YH, Chang RW, Chang CY, Chang KC*.(2014) Pyridoxamine protects against mechanical defects in cardiac ageing in rats: studies on load dependence of myocardial relaxation. Exp Physiol 2014;99.11:1488–1498.
4. Wang CH, Chang RW, Ko YH, Tsai PR, Wang SS, Chen YS, Ko WJ, Chang CY, Young TH, Chang KC*.(2014) Prevention of Arterial Stiffening by Using Low-Dose Atorvastatin in Diabetes Is Associated with Decreased Malondialdehyde. PLoS ONE 2014;9(3):e90471.
5. Wang CH, Wang SS, Ko WJ, Chen YS, Chang CY, Chang RW, Chang KC*.(2013) Acetyl-L-carnitine and oxfenicine on cardiac pumping mechanics in streptozotocin-induced diabetes in male wistar rats. PLoS ONE 2013;8(7):e69977.
6. Wu MS, Chang CY, Chang RW, Chang KC. (2012)
   Early return of augmented wave reflection impairs left ventricular relaxation in aged Fisher 344 rats. Exp Gerontol. 47(9):680-6.
7. Wu ET, Liang JT, Wu MS, Chang KC*. (2011) Pyridoxamine prevents age-related aortic stiffening and vascular resistance in association with reduced collagen glycation. Exp Gerontol 46(6):482-488.
8. Chang KC*, Tseng CD, Lu SC, Liang JT, Wu MS, Tsai PS, Hsu KL. (2010) Effects of acetyl-L-carnitine and oxifenicine on aorta stiffness in diabetic rats. Eur J Clin Invest 40(11):1002-1010
9. Tsai MS, Ko YH, Hsu WM, Liang JT, Lai HS, Lee PH, Chang KC*. (2010) Enhanced aortic nerve growth factor expression and nerve sprouting in rats following gastric perforation. J Surg Res [Epub ahead of print]
10. Tsai MS, Chung SD, Liang JT, Ko YH, Hsu WM, Lai HS, Chang KC*. (2010) Enhanced expression of cardiac nerve growth factor and nerve sprouting markers in rats following gastric perforation: the association with cardiac sympathovagal balance. Shock 33:170-178
11. Chang KC , Liang JT, Tsai PS, Wu MS, Hsu KL. (2009) Prevention of arterial stiffening by pyridoxamine in diabetes is associated with inhibition of the pathogenic glycation on aortic collagen. Br J Pharmacol 157(8):1419-26.
12. Lin YD, Hsu KL, Wu ET, Tsai MS, Wang CH, Chang CY, Chang KC*. (2008) Autonomic neuropathy precedes cardiovascular dysfunction in rats with diabetes. Eur J Clin Invest 38:607-614 (SCI; NTUH 95-000 323)
13. Wu MS, Liang JT, Lin YD, Wu ET, Y-Z Tseng YZ, Chang KC*. (2008) Aminoguanidine prevents deterioration of cardiac pumping mechanics in streptozotocin and nicotinamide-induced type 2 diabetes in rats. Br J Pharmacol 154:758-764 (SCI; NTUH 95-000 323 & NSC 95-2320-B-002-066)
14. Chang KC*, Liang JT, Tseng CD, Hsu KL, Wu MS, Lin YT, Tseng YZ.(2007) Aminoguanidine prevents fructose-induced deterioration in left ventricular-arterial coupling in Wistar Rats. Br J Pharmacol 151:341-346 (SCI; NTUH 95-000 323 & NSC 93-2320-B-002-066)
15. Chang KC*, Tseng CD, Wu MS, Liang JT, Tsai MS, Cho YL, Tseng YZ. (2006)Aminoguanidine prevents arterial stiffening in a new rat model of type 2 diabetes.Eur J Clin Invest 36: 528-535 (SCI; NTUH 94-S017 & NSC 94-2320-B-002-058)
16. Chang KC*, Hsu KL, Tseng CD, Lin YD, Cho YL, Tseng YZ. (2006) Aminoguanidine prevents arterial stiffening and cardiac hypertrophy in streptozotocin induced diabetes in rats. Br J Pharmacol 147: 944-950 (SCI; NTUH 93-S021 & NSC 93-2320-B-002-062)
17. Chang KC*, Tseng CD, Chou TF, Cho YL, Chi TC, Su MJ, Tseng YZ. (2006) Arterial stiffening and cardiac hypertrophy in e new rat model of type 2 diabetes. Eur J Clin Invest 36: 1-7 (SCI; NTUH 94-S017 & NSC 94-2320-B-002-058)
18. Lin YT, Tseng YZ, Chang KC*.(2004) Aminoguanidine prevents fructose-induced arterial stiffening in Wistar rats: aortic impedance analysis. Exp Biol Med 229: 1038-1045(SCI; NTUH 93-S021 and NSC 92-2320-B-002-087)
19. Chang KC*, Hsu KL, Chou TF, Lo HM, Tseng YZ. (2004) Aminoguanidine prevents age-related deterioration in left ventricular-arterial coupling in Fisher 344 rats. Br J Pharmacol 142: 1099-1104 (SCI; NTUH 93-S021 and NSC 92-2320-B-002-087)
20. Chang KC*, Hsu KL, Peng YI, Lee FC, Tseng YZ. (2003) Aminoguanidine prevents age-related aortic stiffening in fisher 344 rats: aortic impedance analysis. British J of pharmacology 140: 107-114
21. Chang KC*, Hsu KL, Tseng YZ. (2003) Effects of diabetes and gender on Mechanical properties of the arterial system in rats: aortic impedance analysis. Exp Biol Med 228: 70-78.
22. Chang KC*, Lo HM, Tsong YZ. (2002) Systolic elastance and resistance in the regulation of cardiac pumping function in early streptozotocin-diabetic rats.Exp Biol Med 227: 251-259 (SCI; NSC 87-2314-B-002-274 and NSC 88-2314-B-002-209)
23. Chang KC*, Su MJ, Peng YI, Shao CC, Wu YC, Tseng YZ. (2001) Mechanical effects of liriodenine on the left ventricular-arterial coupling in Wistar rats: pressure-stroke volume analysis. Br J Pharmacol 133:29-36 (SCI; NSC 88-2314-B002-209)
24. Chang KC*, Peng YI, Tsai YF, Tseng YZ, Chen HI. (2001) Hypotensive effects of captopril on physical properties of the arterial system in young and adult rats. Biogerontology 2(1):45-54 (NSC 87-2314-B-002-274 and NSC 88-2314-B002-209)
25. Chang KC*, Peng YI, Lee FC, Tseng YZ. (2001) Effects of food restriction on systolic mechanical behavior of the ventricular pump in middle-aged and senescent rats. J Gerontol: BS 56A:B108-B114 (SCI; NSC 87-2314-B-002-274 and NSC 88-2314-B002-209)
26. Chang KC*, Peng YI, Dai SH, Tseng YZ. (2000) Age-related changes in pumping mechanical behavior of rat ventricle in terms of systolic elastance and resistance.
    J Gerontol: BS 55A:B440-B447(SCI; NSC 87-2314-B-002-274 and NSC 88-2314-B002-209)
27. Chang KC*,Chen TJ, Peng YI, Li TH, Tseng YZ. (2000) Impaired vascular dynamics in normotensive diabetic rats induced by streptozotocin: tapered T-tube model analysis. J Theor Biol 204:371-380 (SCI; NSC 83-0412-B-002-230)
28. Peng YI, Chang KC*.(2000) Acute effects of methoxamine on left ventricular-arterial coupling in streptozotocin-diabetic rats: pressure-volume analysis. Canadian J Physiol Pharmacol 78:415-422 (SCI; NSC 87-2314-B-002-274 and NSC 89-2320-B-002-115)
29. Chang KC*, Chow CY, Peng YI, Chen TJ, Tsai YF. (1999) Effects of food restriction on mechanical properties of arterial system in adult and middle-aged rats.
    J Gerontol:BS 54A:B441-B447 (SCI; NSC 87-2314-B-002-274)
30. Chang KC*. (1998) Theoretical maximal flow of the left ventricle is sensitive to change in ventricular afterload. J Theor Biol 194:409-417 (SCI; NSC 87-2314-B-002-274)
31. Chang KC*. (1998) Hypertensive effects of methoxamine on the arterial mechanics in rats: analysis based on exponentially tapered T-tube model. Eur J Pharmacol 350:195-202 (SCI; NSC 86-2314-B-002-093-M04)
32. Chang KC*, Tsai YF, Chow CY, Peng YI, Chen TJ. (1998) Age-related changes of arterial mechanical properties in rats: analysis using exponentially tapered T-tube model. J Gerontol BS 53A:B274-B280 (SCI; NSC 86-2314-B002-093-M04)
33. Hu CT, Chang KC, Wu CY, Chen HI*. (1997) Acute effects of nitric oxide blockade with L_NAME on arterial haemodynamics in the rat. Br J Pharmacol 122:1237-1243
    (SCI; NSC 85-2331-B320-001)
34. Chang KC*, Kuo TS. (1997) Single-beat estimation of the ventricular pumping mechanics in terms of the systolic elastance and resistance. J Theor Biol 189: 89-95 (SCI; NSC 82-0412-B002-427)
35. Chang KC*, Kuo TS. (1996) Exponentially tapered t-tube model in characterizing arterial non-uniformity. J Theor Biol 183:35-46 (SCI; NSC 81-0412-B002-634)
36. Chang KC*. (1996) Reply to Professor Burattini‘s comments on “Exponentially tapered t-tube model of systemic arterial system in dogs.” Med Eng Phys 18:336-338
    (SCI; NSC 81-0412-B002-634)
37. Chang KC*, Tseng YZ, Kuo TS, Chen HI. (1995) Impedance and wave reflection in arterial system: simulation with geometrically tapered T-tubes. Med and Biol Eng and Comput 33: 652-660 (SCI; NSC 81-0412-B002-634)
38. Chang KC*, Lo HM, Lin FY, Tseng YZ, Ko FN, Teng CM. (1995) Effects of dicentrine on the properties of syetemic arterial trees in dogs. J Cardiovas Pharmacol 26:169-176 (SCI; NSC 83-0412-B002-230)
39. Hu CT, Chang KC, Kuo TS, Chen HI*. (1994) The correlation of cardiac mass with arterial haemodynamics of resistive and capacitive load in rats with normotension and established hypertension. Pflug Arch Eur J Physiol 428:533-541(SCI; NSC 80-0412-B016-133)
40. Chang KC*, Tseng YZ, Kuo TS, Chen HI. (1994) Impaired left ventricular relaxation and arterial stiffness in patients with essential hypertension. Clin Sci 87:641-647 (SCI; NSC 82-0412-B002-427)
41. Chang KC*, Tseng YZ, Lin YJ, Kuo TS, Chen HI. (1994) Exponentially tapered T-tube model of systemic arterial system in dogs. Med Eng Phys16:370-378 (SCI; NSC 81-0412-B002-634)
42. Chen HI*, Chang KC, Liu HC, Lin CH. (1993) Acute adaptation and resetting of the baroreflex control of vascular resistance in the canine hindquarters and mesentery. Pflug Arch Eur J Phy 424:276-284 (SCI; NSC 80-0412-B016-04)
43. Chang KC*, Kuo TS, Chen HI. (1992) Prediction of input impedance by an asymmetric T-tube terminated with an opportune complex load. J Chinese Inst Eng 5:533-547 (NSC 79-0412-B016-137)
44. Chen HI*, Chang KC. (1991) Assessment of baroreflex threshold and saturation pressure: A new mathematic analysis. Jpn J Physiol 41:861-877 (SCI; NSC 79-0412-B016-01)
45. Chen HI*, Chang KC, Hsieh KS. (1991) Vascular factors in isovolumic systemic and pulmonary circuit. Am J Physiol 260:H201-H209 (SCI; NSC 78-0412-B016-03)
46. Chang KC, Hsieh KS, Kuo TS, Chen HI*. (1990) Effects of nifedipine on systemic hydraulic vascular load in patients with hypertension. Cardiovas Res 24:719-726 (SCI; NSC 76-0412-B016-37)