成員簡介

張國柱名譽教授

張國柱名譽教授

  • 張國柱

  • 職  稱：名譽教授
  • 學  歷：臺灣大學 博士
  • 專  長：循環生理學
  • 聯絡電話：(02)23123456 ext 88243
  • E-mail：kcchang1008@ntu.edu.tw

本實驗室對心血管力學的研究如下：

（1）發展指數函數之非均勻性Ｔ管模型(exponentially tapered T-tube model)以探討體循環動脈管之物理性質。吾人發現老鼠之血管阻力與特徵阻抗隨年齡的增加而下降，然而量化大動脈管硬度(arterial stiffness)的脈波傳輸時間卻不受年齡所影響，這意謂著直至十八個月大的老鼠，其大動脈管以及阻力性血管皆有擴展(dilatation)的現象。吾人亦發現節食可降低血管阻力以及特徵阻抗，然而卻不影響脈波的傳輸時間，這意謂著經過半年的隔天給食，支配十二個月大老鼠之心血管的交感神經興奮性有降低的現象。雖然節食可增加十二個月大及十八個月大老鼠的動脈容積度(arterial compliance)，但其機制卻不盡相同。Nichols教授（血行力學經典之作"McDonald's Blood Flow in Arteries" 1990和1998年版作者之一）曾撰寫一篇具肯定性的文章發表於2000年一月份的Journal of Gerontology-Biological Sciences，此評論對本實驗室之鼓勵甚巨。
 
（2）運用彈性-阻力模型(elastance-resistance model)來探討血管之收縮力學(systolic mechanics)。吾人發現老化老鼠心室收縮力的下降可能肇因於調控心肌長度的鈣離子敏感性的機制(length-dependent mechanism for Ca2+ sensitivity)受到傷害，此傷害可經由節食所導正而恢復心室收縮力；此外，老化鼠等效動脈彈性的降低可能導致心室內部收縮阻力的下降，然而心室內部阻力之下降不受節食所影響。吾人亦發現，以streptozotocin (STZ)所誘發之早期糖尿病鼠具有與老化鼠相同趨勢之心臟收縮力學的變化。
 
（3）使用彈性模型(time-varying elastance model)來探討心室-動脈管之交互作用(ventricular-arterial coupling or interaction)。當心室之末期收縮彈性與動脈之等效彈性相匹配時，動脈可從心室獲取最大的能量。吾人發現STZ-糖尿病鼠之等效動脈彈性的下降遠超過心室末期收縮彈性的下降，這將降低左心室傳輸至動脈管的能量。本實驗室亦評估liriodenine與quinidine之類抗心律不整的藥物對心血管交互作用的影響，發現在有效劑量下，liriodenine幾乎不影響心臟與血管的力學以及心室-動脈管的交互作用。反觀quinidine則相當程度地減少等效動脈彈性而降低心室與動脈管的匹配，這使得能量從左心室傳輸到動脈系統受到傷害。
 
（4）吾人使用核醫心臟攝影所得之時間-活性曲線(time-activity curve)來探討心室之舒張功能。基本上，等體積舒張期、快速填充期、diastasis以及心房收縮期很難界定。本實驗室發展一套電腦計算規則可自動界定二尖瓣的開啟(mitral valve opening)、快速填充期的結束以及心房收縮的開始。吾人發現，在尚無心室肥厚的情況下，高血壓病患因其大動脈管的硬化使得脈波反射增強而延長了等體積舒張期，這可為心室收縮功能趨壞的先期指標。未來，在臨床上期望能近一步探討年齡與性別對心室之舒張與收縮功能的影響，以及糖尿病對心室之舒張與收縮功能的影響。

著作目錄（*代表通訊作者）

  1. Wang CH, Chang RW, Chang CY, Wu MS, Kao HL, Lai LC, Young TH, Yu HY, Chen YS, Chang KC. Quantification of contractile mechanics in the rat heart from ventricular pressure alone. Oncotarget Advance Publications 2017. https://doi.org/10.18632/oncotarget.21815
  2. Chang CY Chang, Chang RW, Hsu SH, Wu MS, Cheng YJ, Kao HL, Lai LC, Wang CH, Chang KC. Defects in vascular mechanics due to aging in rats: Studies on arterial wave properties from a single aortic pressure pulse. Front Physiol 8:503. doi: 10.3389/fphys.2017.00503
  3. Chang RW, Chang CY, Lai LC, Wu MS, Young TH, Chen YS, Wang CH*, Chang KC*. Determining arterial wave transit time from a single aortic pressure pulse in rats: vascular impulse response analysis. Scientific Reports | 7:40998 | DOI: 10.1038/srep40998 (2017).
  4.  Chang RW, Chang CY, Wu MS, Yu HY, Luo JM, Chen YS, Lin FY, Lai LC, Wang CH*, Chang KC*. Systolic aortic pressure-time area is a useful index describing arterial wave properties in rats with diabetes. Scientific Reports | 5:17293 | DOI: 10.1038/srep17293 (2015).
  5. Ko YH, Tsai MS, Chang RW, Chang CY, Wang CH, Wu MS, Liang JT, Chang KC*. Methylprednisolone protects cardiac pumping mechanics from deteriorating in lipopolysaccharide-treated rats. Front Physiol 6:348. doi: 10.3389/fphys.2015.00348.
  6. Wang CH, Wu ET, Wu MS, Tsai MS, Ko YH, Chang RW, Chang CY, Chang KC*. Pyridoxamine protects against mechanical defects in cardiac ageing in rats: studies on load dependence of myocardial relaxation. Exp Physiol 2014;99.11:1488–1498.
  7. Wang CH, Chang RW, Ko YH, Tsai PR, Wang SS, Chen YS, Ko WJ, Chang CY, Young TH, Chang KC*. Prevention of Arterial Stiffening by Using Low-Dose Atorvastatin in Diabetes Is Associated with Decreased Malondialdehyde. PLoS ONE 2014;9(3):e90471.
  8. Wang CH, Wang SS, Ko WJ, Chen YS, Chang CY, Chang RW, Chang KC*. Acetyl-L-carnitine and oxfenicine on cardiac pumping mechanics in streptozotocin-induced diabetes in male wistar rats. PLoS ONE 2013;8(7):e69977.
  9. Ko YH, Tsai MS, Lee PH, Liang JT, Chang KC*. Methylprednisolone stiffens aortas in lipopolysaccharide-induced chronic inflammation in rats. PLoS ONE 2013;8(7):e69636.
  10.  Wu MS, Chang CY, Chang RW, Chang KC*. Early return of augmented wave reflection impairs left ventricular relaxation in aged Fisher 344 rats. Exp Gerontol 2012;47:680–686.
  11. Tsai MS, Ko YH, Hsu WM, Liang JT, Lai HS, Lee PH, Chang KC*. Enhanced aortic nerve growth factor expression and nerve sprouting in rats following gastric perforation. J Surg Res 2011;171(1):205-211 (SCI; NSC 98-2314-B-002-054-MY2, NTUH 98-N1228).
  12. Wu ET, Liang JT, Wu MS, Chang KC*. Pyridoxamine prevents age-related aortic stiffening and vascular resistance in association with reduced collagen glycation. Exp Gerontol 2011;46(6):482-488 (SCI; NSC 97-2320-B-002-040-MY3).
  13. Chang KC*, Tseng CD, Lu SC, Liang JT, Wu MS, Tsai PS, Hsu KL. Effects of acetyl-L-carnitine and oxifenicine on aorta stiffness in diabetic rats. Eur J Clin Invest 2010;40(11):1002-1010 (SCI; NSC 97-2320-B-002-040-MY3).
  14. Tsai MS, Chung SD, Liang JT, Ko YH, Hsu WM, Lai HS, Chang KC*. Enhanced expression of cardiac nerve growth factor and nerve sprouting markers in rats following gastric perforation: the association with cardiac sympathovagal balance. Shock 2010;33:170-178 (SCI; NTUH 97-N1006, NTUH 98-N1228, NTUH 97-FTN17, and NTUHYL 96-N017).
  15. Chang KC*, Liang JT, Tsai PS, Wu MS, Hsu KL. Prevention of arterial stiffening by pyridoxamine in diabetes is associated with inhibition of the pathogenic glycation on aortic collagen. Br J Pharmacol 2009;157:1419-1426 (SCI; NTUH 97-N976).
  16. Lin YD, Hsu KL, Wu ET, Tsai MS, Wang CH, Chang CY, Chang KC*. Autonomic neuropathy precedes cardiovascular dysfunction in rats with diabetes. Eur J Clin Invest 2008;38:607-614 (SCI; NTUH 95-000 323).
  17. Wu MS, Liang JT, Lin YD, Wu ET, Y-Z Tseng YZ, Chang KC*. Aminoguanidine prevents deterioration of cardiac pumping mechanics in streptozotocin and nicotinamide-induced type 2 diabetes in rats. Br J Pharmacol 2008;154:758-764 (SCI; NTUH 95-000 323 & NSC 95-2320-B-002-066).
  18. Chang KC*, Liang JT, Tseng CD, Hsu KL, Wu MS, Lin YT, Tseng YZ. Aminoguanidine prevents fructose-induced deterioration in left ventricular-arterial coupling in Wistar Rats. Br J Pharmacol 2007;151:341-346 (SCI; NTUH 95-000 323 & NSC 93-2320-B-002-066).
  19. Chang KC*, Tseng CD, Wu MS, Liang JT, Tsai MS, Cho YL, Tseng YZ. Aminoguanidine prevents arterial stiffening in a new rat model of type 2 diabetes. Eur J Clin Invest 2006;36:528-535 (SCI; NTUH 94-S017 & NSC 94-2320-B-002-058).
  20. Chang KC*, Hsu KL, Tseng CD, Lin YD, Cho YL, Tseng YZ. Aminoguanidine prevents arterial stiffening and cardiac hypertrophy in streptozotocin induced diabetes in rats. Br J Pharmacol 2006;147:944-950 (SCI; NTUH 93-S021 & NSC 93-2320-B-002-062).
  21. Chang KC*, Tseng CD, Chou TF, Cho YL, Chi TC, Su MJ, Tseng YZ. Arterial stiffening and cardiac hypertrophy in a new rat model of type 2 diabetes. Eur J Clin Invest 2006;36:1-7 (SCI; NTUH 94-S017 & NSC 94-2320-B-002-058).
  22. Lin YT, Tseng YZ, Chang KC*. Aminoguanidine prevents fructose-induced arterial stiffening in Wistar rats: aortic impedance analysis. Exp Biol Med 2004;229:1038-1045 (SCI; NTUH 93-S021 & NSC 92-2320-B-002-087).
  23. Chang KC*, Hsu KL, Chou TF, Lo HM, Tseng YZ. Aminoguanidine prevents age-related deterioration in left ventricular-arterial coupling in Fisher 344 rats. Br J Pharmacol 2004;142:1099-1104 (SCI; NTUH 93-S021 & NSC 92-2320-B-002-087).
  24. Chang KC*, Hsu KL, Peng YI, Lee FC, Tseng YZ. Aminoguanidine prevents age-related aortic stiffening in Fisher 344 rats: aortic impedance analysis. Br J Pharmacol 2003;140:107-114 (SCI; NTUH 92-S022 & NSC 88-2314-B-002-209).
  25. Chang KC*, Hsu KL, Tseng YZ. Effects of diabetes and gender on mechanical properties of the arterial system in rats: aortic impedance analysis. Exp Biol Med 2003;228:70-78 (SCI; NTUH 92-S022).
  26. Chang KC*, Lo HM, Tseng YZ. Systolic elastance and resistance in the regulation of cardiac pumping function in early streptozotocin-diabetic rats. Exp Biol Med 2002;227(4):251-259 (SCI; NSC 88-2314-B002-209).
  27. Chang KC*, Su MJ, Peng YI, Shao CC, Wu YC, Tseng YZ. Mechanical effects of liriodenine on the left ventricular-arterial coupling in Wistar rats: pressure-stroke volume analysis. Br J Pharmacol 2001;133:29-36 (SCI; NSC 89-2320-B002-115).
  28. Chang KC*, Peng YI, Tsai YF, Tseng YZ, Chen HI. Hypotensive effects of captopril on physical properties of the arterial system in young and adult rats. Biogerontology 2001;2(1):45-54 (SCI; NSC 87-2314-B-002-274 and NSC 88-2314-B002-209).
  29. Chang KC*, Peng YI, Lee FC, Tseng YZ. Effects of food restriction on systolic mechanical behavior of the ventricular pump in middle-aged and senescent rats. J Gerontol:BS 2001;56A:B108-B114 (SCI; NSC 88-2314-B002-209).
  30. Change KC*, Peng YI, Dai SH, Tseng YZ. Age-related changes in pumping mechanical behavior of rat ventricle in terms of systolic elastance and resistance. J Gerontol:BS 2000;55A:B440-B447 (SCI; NSC 87-2314-B-002-274 and NSC 88-2314-B002-209).
  31. Chang KC*, Chen TJ, Peng YI, Li TH, Tseng YZ. Impaired vascular dynamics in normotensive diabetic rats induced by streptozotocin: tapered T-tube model analysis. J Theor Biol 2000;204:371-380 (SCI; NSC 83-0412-B-002-230).
  32. Peng YI, Chang KC*. Acute effects of methoxamine on left ventricular-arterial coupling in streptozotocin-diabetic rats: pressure-volume analysis. Canadian J Physiol Pharmacol 2000;78:415-422 (SCI; NSC 87-2314-B-002-274 and NSC 89-2320-B-002-115).
  33. Chang KC*, Chow CY, Peng YI, Chen TJ, Tsai YF. Effects of food restriction on mechanical properties of arterial system in adult and middle-aged rats. J Gerontol:BS 1999;54A:B441-B447 (SCI; NSC 87-2314-B-002-274).
  34. Chang KC*. Theoretical maximal flow of the left ventricle is sensitive to change in ventricular afterload. J Theor Biol 1998;194:409-417 (SCI; NSC 87-2314-B-002-274).
  35. Chang KC*. Hypertensive effects of methoxamine on the arterial mechanics in rats: analysis based on exponentially tapered T-tube model. Eur J Pharmacol 1998;350:195-202 (SCI; NSC 86-2314-B-002-093-M04) .
  36. Chang KC*, Tsai YF, Chow CY, Peng YI, Chen TJ. Age-related changes of arterial mechanical properties in rats: analysis using exponentially tapered T-tube model. J Gerontol:BS 1998;53A:B274-B280 (SCI; NSC 86-2314-B002-093-M04).
  37. Hu CT, Chang KC, Wu CY, Chen HI*. Acute effects of nitric oxide blockade with L_NAME on arterial haemodynamics in the rat. Br J Pharmacol 1997;122:1237-1243 (SCI; NSC 85-2331-B320-001).
  38. Chang KC*, Kuo TS. Single-beat estimation of the ventricular pumping mechanics in terms of the systolic elastance and resistance. J Theor Biol 1997;189:89-95 (SCI; NSC 82-0412-B002-427).
  39. Chang KC*, Kuo TS. Exponentially tapered t-tube model in characterizing arterial non-uniformity. J Theor Biol 1996;183:35-46 (SCI; NSC 81-0412-B002-634).
  40. Chang KC*. Reply to Professor Burattini‘s comments on “Exponentially tapered t-tube model of systemic arterial system in dogs.” Med Eng Phys 1996;18:336-338 (SCI; NSC 81-0412-B002-634).
  41. Chang KC*, Tseng YZ, Kuo TS, Chen HI. Impedance and wave reflection in arterial system: simulation with geometrically tapered T-tubes. Med & Biol Eng & Comput 1995;33,652-660 (SCI; NSC 81-0412-B002-634).
  42. Chang KC*, Lo HM, Lin FY, Tseng YZ, Ko FN, Teng CM. Effects of dicentrine on the properties of syetemic arterial trees in dogs. J Cardiovas Pharmacol 1995;26:169-176 (SCI; NSC 83-0412-B002-230).
  43. Hu CT, Chang KC, Kuo TS, Chen HI*. The correlation of cardiac mass with arterial haemodynamics of resistive and capacitive load in rats with normotension and established hypertension. Pflug Arch Eur J Physiol 1994;428:533-541 (SCI; NSC 80-0412-B016-133).
  44. Chang KC*, Tseng YZ, Kuo TS, Chen HI. Impaired left ventricular relaxation and arterial stiffness in patients with essential hypertension. Clin Sci 1994;87:641-647 (SCI; NSC 82-0412-B002-427).
  45. Chang KC*, Tseng YZ, Lin YJ, Kuo TS, Chen HI. Exponentially tapered T-tube model of systemic arterial system in dogs. Med Eng Phys 1994;16:370-378 (SCI; NSC 81-0412-B002-634).
  46. Chen HI*, Chang KC, Liu HC, Lin CH. Acute adaptation and resetting of the baroreflex control of vascular resistance in the canine hindquarters and mesentery. Pflug Arch Eur J Physiol 1993;424:276-284 (SCI; NSC 80-0412-B016-04).
  47. Chang KC*, Kuo TS, Chen HI. Prediction of input impedance by an asymmetric T-tube terminated with an opportune complex load. J Chinese Inst Eng 1992;5:533-547 (NSC 79-0412-B016-137).
  48. Chen HI*, Chang KC. Assessment of baroreflex threshold and saturation pressure: A new mathematic analysis. Jpn J Physiol 1991;41:861-877 (SCI; NSC 79-0412-B016-01).
  49. Chen HI*, Chang KC, Hsieh KS. Vascular factors in isovolumic systemic and pulmonary circuit. Am J Physiol 1991;260:H201-H209 (SCI; NSC 78-0412-B016-03).
  50. Chang KC, Hsieh KS, Kuo TS, Chen HI*. Effects of nifedipine on systemic hydraulic vascular load in patients with hypertension. Cardiovas Res 1990;24:719-726 (SCI; NSC 76-0412-B-016-37).

Kuo-Chu Chang was born in Taiwan in 1952. In 1991, he received his PhD degree from the Section of Biomedical Engineering, Institute of Electrical Engineering, National Taiwan University. He is now Professor in Physiology at the College of Medicine, National Taiwan University. His main research interests include the modeling of the systemic arterial tree and the systolic mechanical properties of the ventricular pump.

Publication Lists:

  1. Chang RW, Chang CY, Wu MS, Yu HY, Luo JM, Chen YS, Lin FY, Lai LC, Wang CH*, Chang KC*. Systolic aortic pressure-time area is a useful index describing arterial wave properties in rats with diabetes. Scientific Reports | 5:17293 | DOI: 10.1038/srep17293.
  2. Ko YH, Tsai MS, Chang RW, Chang CY, Wang CH, Wu MS, Liang JT, Chang KC*.(2015) Methylprednisolone protects cardiac pumping mechanics from deteriorating in lipopolysaccharide-treated rats. Front Physiol 6:348. doi: 10.3389/fphys.2015.00348.
  3. Wang CH, Wu ET, Wu MS, Tsai MS, Ko YH, Chang RW, Chang CY, Chang KC*.(2014) Pyridoxamine protects against mechanical defects in cardiac ageing in rats: studies on load dependence of myocardial relaxation. Exp Physiol 2014;99.11:1488–1498.
  4. Wang CH, Chang RW, Ko YH, Tsai PR, Wang SS, Chen YS, Ko WJ, Chang CY, Young TH, Chang KC*.(2014) Prevention of Arterial Stiffening by Using Low-Dose Atorvastatin in Diabetes Is Associated with Decreased Malondialdehyde. PLoS ONE 2014;9(3):e90471.
  5. Wang CH, Wang SS, Ko WJ, Chen YS, Chang CY, Chang RW, Chang KC*.(2013) Acetyl-L-carnitine and oxfenicine on cardiac pumping mechanics in streptozotocin-induced diabetes in male wistar rats. PLoS ONE 2013;8(7):e69977.
  6. Wu MS, Chang CY, Chang RW, Chang KC. (2012)
    Early return of augmented wave reflection impairs left ventricular relaxation in aged Fisher 344 rats. Exp Gerontol. 47(9):680-6.
  7. Wu ET, Liang JT, Wu MS, Chang KC*. (2011) Pyridoxamine prevents age-related aortic stiffening and vascular resistance in association with reduced collagen glycation. Exp Gerontol 46(6):482-488.
  8. Chang KC*, Tseng CD, Lu SC, Liang JT, Wu MS, Tsai PS, Hsu KL. (2010) Effects of acetyl-L-carnitine and oxifenicine on aorta stiffness in diabetic rats. Eur J Clin Invest 40(11):1002-1010
  9. Tsai MS, Ko YH, Hsu WM, Liang JT, Lai HS, Lee PH, Chang KC*. (2010) Enhanced aortic nerve growth factor expression and nerve sprouting in rats following gastric perforation. J Surg Res [Epub ahead of print]
  10. Tsai MS, Chung SD, Liang JT, Ko YH, Hsu WM, Lai HS, Chang KC*. (2010) Enhanced expression of cardiac nerve growth factor and nerve sprouting markers in rats following gastric perforation: the association with cardiac sympathovagal balance. Shock 33:170-178
  11. Chang KC , Liang JT, Tsai PS, Wu MS, Hsu KL. (2009) Prevention of arterial stiffening by pyridoxamine in diabetes is associated with inhibition of the pathogenic glycation on aortic collagen. Br J Pharmacol 157(8):1419-26.
  12. Lin YD, Hsu KL, Wu ET, Tsai MS, Wang CH, Chang CY, Chang KC*. (2008) Autonomic neuropathy precedes cardiovascular dysfunction in rats with diabetes. Eur J Clin Invest 38:607-614 (SCI; NTUH 95-000 323)
  13. Wu MS, Liang JT, Lin YD, Wu ET, Y-Z Tseng YZ, Chang KC*. (2008) Aminoguanidine prevents deterioration of cardiac pumping mechanics in streptozotocin and nicotinamide-induced type 2 diabetes in rats. Br J Pharmacol 154:758-764 (SCI; NTUH 95-000 323 & NSC 95-2320-B-002-066)
  14. Chang KC*, Liang JT, Tseng CD, Hsu KL, Wu MS, Lin YT, Tseng YZ.(2007) Aminoguanidine prevents fructose-induced deterioration in left ventricular-arterial coupling in Wistar Rats. Br J Pharmacol 151:341-346 (SCI; NTUH 95-000 323 & NSC 93-2320-B-002-066)
  15. Chang KC*, Tseng CD, Wu MS, Liang JT, Tsai MS, Cho YL, Tseng YZ. (2006)Aminoguanidine prevents arterial stiffening in a new rat model of type 2 diabetes.Eur J Clin Invest 36: 528-535 (SCI; NTUH 94-S017 & NSC 94-2320-B-002-058)
  16. Chang KC*, Hsu KL, Tseng CD, Lin YD, Cho YL, Tseng YZ. (2006) Aminoguanidine prevents arterial stiffening and cardiac hypertrophy in streptozotocin induced diabetes in rats. Br J Pharmacol 147: 944-950 (SCI; NTUH 93-S021 & NSC 93-2320-B-002-062)
  17. Chang KC*, Tseng CD, Chou TF, Cho YL, Chi TC, Su MJ, Tseng YZ. (2006) Arterial stiffening and cardiac hypertrophy in e new rat model of type 2 diabetes. Eur J Clin Invest 36: 1-7 (SCI; NTUH 94-S017 & NSC 94-2320-B-002-058)
  18. Lin YT, Tseng YZ, Chang KC*.(2004) Aminoguanidine prevents fructose-induced arterial stiffening in Wistar rats: aortic impedance analysis. Exp Biol Med 229: 1038-1045(SCI; NTUH 93-S021 and NSC 92-2320-B-002-087)
  19. Chang KC*, Hsu KL, Chou TF, Lo HM, Tseng YZ. (2004) Aminoguanidine prevents age-related deterioration in left ventricular-arterial coupling in Fisher 344 rats. Br J Pharmacol 142: 1099-1104 (SCI; NTUH 93-S021 and NSC 92-2320-B-002-087)
  20. Chang KC*, Hsu KL, Peng YI, Lee FC, Tseng YZ. (2003) Aminoguanidine prevents age-related aortic stiffening in fisher 344 rats: aortic impedance analysis. British J of pharmacology 140: 107-114
  21. Chang KC*, Hsu KL, Tseng YZ. (2003) Effects of diabetes and gender on Mechanical properties of the arterial system in rats: aortic impedance analysis. Exp Biol Med 228: 70-78.
  22. Chang KC*, Lo HM, Tsong YZ. (2002) Systolic elastance and resistance in the regulation of cardiac pumping function in early streptozotocin-diabetic rats.Exp Biol Med 227: 251-259 (SCI; NSC 87-2314-B-002-274 and NSC 88-2314-B-002-209)
  23. Chang KC*, Su MJ, Peng YI, Shao CC, Wu YC, Tseng YZ. (2001) Mechanical effects of liriodenine on the left ventricular-arterial coupling in Wistar rats: pressure-stroke volume analysis. Br J Pharmacol 133:29-36 (SCI; NSC 88-2314-B002-209)
  24. Chang KC*, Peng YI, Tsai YF, Tseng YZ, Chen HI. (2001) Hypotensive effects of captopril on physical properties of the arterial system in young and adult rats. Biogerontology 2(1):45-54 (NSC 87-2314-B-002-274 and NSC 88-2314-B002-209)
  25. Chang KC*, Peng YI, Lee FC, Tseng YZ. (2001) Effects of food restriction on systolic mechanical behavior of the ventricular pump in middle-aged and senescent rats. J Gerontol: BS 56A:B108-B114 (SCI; NSC 87-2314-B-002-274 and NSC 88-2314-B002-209)
  26. Chang KC*, Peng YI, Dai SH, Tseng YZ. (2000) Age-related changes in pumping mechanical behavior of rat ventricle in terms of systolic elastance and resistance.
    J Gerontol: BS 55A:B440-B447(SCI; NSC 87-2314-B-002-274 and NSC 88-2314-B002-209)
  27. Chang KC*,Chen TJ, Peng YI, Li TH, Tseng YZ. (2000) Impaired vascular dynamics in normotensive diabetic rats induced by streptozotocin: tapered T-tube model analysis. J Theor Biol 204:371-380 (SCI; NSC 83-0412-B-002-230)
  28. Peng YI, Chang KC*.(2000) Acute effects of methoxamine on left ventricular-arterial coupling in streptozotocin-diabetic rats: pressure-volume analysis. Canadian J Physiol Pharmacol 78:415-422 (SCI; NSC 87-2314-B-002-274 and NSC 89-2320-B-002-115)
  29. Chang KC*, Chow CY, Peng YI, Chen TJ, Tsai YF. (1999) Effects of food restriction on mechanical properties of arterial system in adult and middle-aged rats.
    J Gerontol:BS 54A:B441-B447 (SCI; NSC 87-2314-B-002-274)
  30. Chang KC*. (1998) Theoretical maximal flow of the left ventricle is sensitive to change in ventricular afterload. J Theor Biol 194:409-417 (SCI; NSC 87-2314-B-002-274)
  31. Chang KC*. (1998) Hypertensive effects of methoxamine on the arterial mechanics in rats: analysis based on exponentially tapered T-tube model. Eur J Pharmacol 350:195-202 (SCI; NSC 86-2314-B-002-093-M04)
  32. Chang KC*, Tsai YF, Chow CY, Peng YI, Chen TJ. (1998) Age-related changes of arterial mechanical properties in rats: analysis using exponentially tapered T-tube model. J Gerontol BS 53A:B274-B280 (SCI; NSC 86-2314-B002-093-M04)
  33. Hu CT, Chang KC, Wu CY, Chen HI*. (1997) Acute effects of nitric oxide blockade with L_NAME on arterial haemodynamics in the rat. Br J Pharmacol 122:1237-1243
    (SCI; NSC 85-2331-B320-001)
  34. Chang KC*, Kuo TS. (1997) Single-beat estimation of the ventricular pumping mechanics in terms of the systolic elastance and resistance. J Theor Biol 189: 89-95 (SCI; NSC 82-0412-B002-427)
  35. Chang KC*, Kuo TS. (1996) Exponentially tapered t-tube model in characterizing arterial non-uniformity. J Theor Biol 183:35-46 (SCI; NSC 81-0412-B002-634)
  36. Chang KC*. (1996) Reply to Professor Burattini‘s comments on “Exponentially tapered t-tube model of systemic arterial system in dogs.” Med Eng Phys 18:336-338
    (SCI; NSC 81-0412-B002-634)
  37. Chang KC*, Tseng YZ, Kuo TS, Chen HI. (1995) Impedance and wave reflection in arterial system: simulation with geometrically tapered T-tubes. Med and Biol Eng and Comput 33: 652-660 (SCI; NSC 81-0412-B002-634)
  38. Chang KC*, Lo HM, Lin FY, Tseng YZ, Ko FN, Teng CM. (1995) Effects of dicentrine on the properties of syetemic arterial trees in dogs. J Cardiovas Pharmacol 26:169-176 (SCI; NSC 83-0412-B002-230)
  39. Hu CT, Chang KC, Kuo TS, Chen HI*. (1994) The correlation of cardiac mass with arterial haemodynamics of resistive and capacitive load in rats with normotension and established hypertension. Pflug Arch Eur J Physiol 428:533-541(SCI; NSC 80-0412-B016-133)
  40. Chang KC*, Tseng YZ, Kuo TS, Chen HI. (1994) Impaired left ventricular relaxation and arterial stiffness in patients with essential hypertension. Clin Sci 87:641-647 (SCI; NSC 82-0412-B002-427)
  41. Chang KC*, Tseng YZ, Lin YJ, Kuo TS, Chen HI. (1994) Exponentially tapered T-tube model of systemic arterial system in dogs. Med Eng Phys16:370-378 (SCI; NSC 81-0412-B002-634)
  42. Chen HI*, Chang KC, Liu HC, Lin CH. (1993) Acute adaptation and resetting of the baroreflex control of vascular resistance in the canine hindquarters and mesentery. Pflug Arch Eur J Phy 424:276-284 (SCI; NSC 80-0412-B016-04)
  43. Chang KC*, Kuo TS, Chen HI. (1992) Prediction of input impedance by an asymmetric T-tube terminated with an opportune complex load. J Chinese Inst Eng 5:533-547 (NSC 79-0412-B016-137)
  44. Chen HI*, Chang KC. (1991) Assessment of baroreflex threshold and saturation pressure: A new mathematic analysis. Jpn J Physiol 41:861-877 (SCI; NSC 79-0412-B016-01)
  45. Chen HI*, Chang KC, Hsieh KS. (1991) Vascular factors in isovolumic systemic and pulmonary circuit. Am J Physiol 260:H201-H209 (SCI; NSC 78-0412-B016-03)
  46. Chang KC, Hsieh KS, Kuo TS, Chen HI*. (1990) Effects of nifedipine on systemic hydraulic vascular load in patients with hypertension. Cardiovas Res 24:719-726 (SCI; NSC 76-0412-B016-37)