吳美玲名譽教授

吳美玲教授

學歷：英國牛津大學生理學博士

經歷：英國劍橋大學影像研究中心研究(Visiting Professor)

現任：臺大醫學院生理學科專任教授、臺灣大學終身特聘教授

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癌症乃是國內外造成死亡原因的首位。目前以外科切除及傳統化療對許多惡性腫瘤仍無法有效治愈，因此對於癌症之分子機制研究及治療惡性腫瘤之藥物研發仍占醫學研究論文發表之首位。引發腫瘤之分子機制包括: (1).oncogenic signals造成許多抗腫瘤蛋白質表現減弱；(2).在缺氧環境引起腫瘤蛋白質之活性增加；(3).粒線體基因突變造成粒線體功能失常；(4).EGF receptor over-expression或是receptor tyrosine kinase domain 之基因突變，導致EGF receptor過度活化 ; (5).腫瘤細胞代謝激酶之基因突變等等。本研究室目前進行之主要研究，乃以高度惡性腫瘤細胞株為研究材料，以microarrays、分子生物學、及分子影像醫學相關之細胞生物技術，研究癌細胞增生之分子機轉，並研發對抗惡性腫瘤細胞增生之藥物，另外也將進行抗腫瘤藥物對抗腫瘤生長之動物模式研究。

(a)對於碩士班畢業資格，並無特別要求。
(b)博士班學生則希望在3~4年當中，有一篇較完整之論文發表 (在該領域 <15%)，及另外一篇較簡短之論文 (在該領域 <50%)即可。

非常歡迎對上述研究主題有興趣，又具有行動力之研究生加入本研究室。

教學
北美校友會 教學優良獎 (1994)
臺大醫學院 教學優良獎 (1995)
臺大醫學院 教學傑出獎 (1997)
臺大醫學院 教學優良獎 (2012)
臺大醫學院 教學優良獎 (2013)

研究
臺大醫學院 青杏醫學研究獎 (1996)
國科會 傑出研究獎 (1997, 1998,  1999, 2000, 2002, 2003, 2004)
國科會 傑出特約研究員 (2005-2008)
臺灣大學 終身特聘教授 (2007-)
國科會 傑出特約研究員 (2013)

1. C-L Lin, H-C Tseng, W-P Chen, M-J Su, Kwang-Ming Fang, R-F Chen and Mei-Lin Wu (Correspondent)*. (2011) Intracellular zinc release-activated ERK-dependent GSK-3β-p53 and Noxa-Mcl-1 signaling are both involved in cardiac ischemic-reperfusion injury. Cell Death & Differentiation (doi:10.1038/cdd.2011.80)
2. Chen JC, Wu ML, Huang KC, Lin WW. (2008) HMG-CoA reductase inhibitors activate the unfolded protein response and induce cytoprotective GRP78 expression.Cardiovasc Res. Oct 1;80(1):138-50.
3. K-M Fang, A-S Lee, M-J Su, C-L Lin, C-L Chien, Wu, M-L. (2008) Free fatty acids act as endogenous ionophores, resulting in Na+ and Ca2+ influx and myocyte apoptosis. Cardiovasc. Res. 78:533-545. (第一作者博士生方光明於 2009獲台大醫學院研究生論文獎第三名)
4. K-M Fang, W-L Chang, S-M Wang, M-J Su, M-L Wu (correspondent) (2008) Arachidonic acid induces both Na+ and Ca2+ entry resulting in apoptosis. J Neurochem 104:1177-1189
5. Yang, K-T., Chang, W-L., Yang, P-C., Chien, C-L., Lai, M-S, Su, M-J., Wu, M-L. (correspondent) (2006) Activation of the transient receptor potential M2 channel and poly(ADP-ribose) polymerase is involved in oxidative stress-induced cardiomyocyte death. Cell Death and Differentiation 13: 1815-1826.
   (第一作者博士生楊昆達於2006台大醫學院研究生論文獎第二名)
6. Yang, K.-T., Pan, S.-F., Chien, C.-L., Hsu, S.-M., Tseng, Y.-Z. , Wang, S.-M. and Wu, M.-L. (correspondent) (2004). Mitochondrial Na+ overload is caused by oxidative stress and leads to activation of the caspase 3-dependent apoptotic machinery. FASEB J 18:1442-1444.
   (第一作者博士生楊昆達獲得2005台大醫學院研究生論文獎第一名)
7. Chen, W.-H., Chen, C.-R., Yang, K.-T., Chang, W.-L., Su, M.-J.,Wu, C.-C. and Wu, M.-L. (correspondent) (2001). Arachidonic acid-induced H+ and Ca2+ increases in both the cytoplasm and nucleoplasm of rat cerebellar granule cells. J. Physiol. (London) 537: 497-510.
   (第一作者博士生陳帷浩台大醫學院研究生論文獎第三名)
8. Wu, M.-L. (correspondent), Chan, C.-C. and Su, M.-J. (2000). Possible mechanism(s) of arachidonic acid-induced intracellular acidosis in rat cardiac myocytes. Circ. Res. 86:e55-e62.
   (第二作者碩士生詹智強獲得2000台大醫學院研究生論文獎第一名)
9. Lin, W.-W., Chang, S.-H. and Wu, M.-L. (correspondent) (1999). Lipoxygenase metabolites as mediators of UTP-induced intracellular acidification in mouse Raw 264.7 macrophages. Mol. Pharmachol. 53:313-321.
   (第二作者碩士生張聖和獲得2000台大醫學院研究生論文獎第二名)
10. Chen, W.-H., Chu, K.-C., Wu, S.-J., Wu, J.-C., Shui, H.-A. and Wu, M.-L. (correspondent) (1999). Early metabolic-induced intracellular sodium and calcium increase in rat cerebellar granule cells. J. Physiol. (London) 515: 133-146.
    (第一作者博士生陳帷浩獲得台大醫學院主治醫師傑出論文獎)
11. Wu, M.-L. (correspondent), Chen, J.-H., Chen, W.-H., Chen, Y.-J. and Chu K.-C. (1999). Novel role of the Ca-ATPase in the NMDA-induced intracellular acidification. Am. J. Physiol. 277: C717-C727.
    (第二作者碩士生陳正豪獲中國生理學會研究生論文獎)
12. Wu, M.-L. (correspodent), Chen, W.-H., Liu, I.-H., Tseng, C.-D. and Wang, S.-M. (1999). A novel effect of cAMP on the capacitative Ca2+ entry in cultured rat cerebellar astrocytes. J. Neurochem. 73: 1318-1328.
13. Liaw, Y.-S., Yang, P.-C., Yu, C.-J., Kuo, S.-H., Luh, K.-T., Lin, Y.-J. and Wu,
    M.-L. (correspondent) (1998). PKC activation is required by EGF-stimulated Na+-H+ exchanger in human pleural mesothelial cells. Am. J. Physiol. 274:L665-L672.
    (第一作者博士生廖永祥獲得台大醫學院研究生論文獎第二名)
14. Chen, Y.-H., Wu, M.-L. and Fu, W.-M. (1998). Regulation of presynaptic NMDA receptors by external and intracellular pH changes at developing neuromuscular synapses. J. Neurosci. 18:2982-2990.
    (第一作者博士生陳豫華獲得台大醫學院研究生論文獎第二名)
15. Chen, Y.-H., Wu, M.-L. and Fu, W.-M. (1998). Regulation of acetylcholin release by intracellular acidification at developing motoneurons in Xenopus cell cultures. J. Physiol. (London) 507: 41-53.
16. Liaw Y-S., Yang, P.-C., Yu, C.-J., Kuo, S.-H., Luh, K.-T., Lin, Y.-J. and Wu, M.-L (correspondent). (1997). Intracellular pH regulation in cultured human pleural mesothelial cells. Am. J. Respir. Crit. Care Med.155: 597-602.
    (第一作者博士生廖永祥獲得台大醫學院主治醫師傑出論文獎)
17. Tsai, K.-L., Wang, S.-M., Chen, C.-C., Fong, T.-H. and Wu, M.-L. (correspondent) (1997). Mechanism of oxidative stress-induced intracellular acidosis in glial cells. J. Physiol. (London) 502: 161-174.
18. Wu, M.-L. and Vaughan-Jones, R.D. (1997). Interaction between Na+ and H+ ions on Na-H exchange in sheep cardiac Purkinje fibers. J. Mol. Cell. Cardiol. 29: 1131-1140.
19. Wu, M.-L. (correspondent), Kao, E.-F., Liu, I.-H., Wang, B.-S. and Lin-Shiau, S.-Y. (1997). The capacitative Ca2+ influx in glial cells is inhibited by glycolytic inhibitors. Glia 21: 315-326.
20. Wu, M.-L., Tsai, K.-L., Wu, J.-C., Wang, S.-M., Wang, B.-S. and Lee, Y.-T. (1996). Mechanism of hydrogen peroxide and hydroxyl free radical-induced intracellular acidification in cultured rat cardiac myoblasts. Circ. Res. 78: 564-572.
    (第二作者碩士生蔡克勵獲得1996台大醫學院研究生論文獎第三名)
21. Chen, C.-C. and Wu, M.-L. (correspondent) (1995). Protein kinase C isoform * is invloved in the stimulation of the Na+-H+ exchanger in C6 glioma cells. Mol. Pharmachol. 48: 995-1003
22. Wu, M.-L., Tsai, M.-L. and Tseng, Y.-Z. (1994). DIDS-sensitive pHi-regulation in single cardiac myocytes in nominally HCO3-free conditions. Circ. Res. 75: 123-132.
    (第二作者碩士生蔡敏麗獲得台灣立青文教基金會研究生論文獎第一名)
23. Wu, M.-L. and Vaughan-Jones, R.D. (1994). Effect of metabolic inhibitors and intracellular messengers upon Na/H exchange in the sheep cardiac Purkinje fibre. J. Physiol. (London) 478: 301-313.
24. Wu, M.-L. and Tseng, Y.-Z. (1993). The modulatory effects of endothelin-1, carbachol and isoprenaline upon Na-H exchange in dog cardiac Purkinje fibres. J. Physiol. (London) 471:583-597.