成員簡介

蘇慧敏副教授

蘇慧敏副教授
  • 蘇慧敏

  • 職  稱:副教授
  • 學  歷:美國康乃爾大學 博士
  • 專  長:內分泌及營養學
  • 聯絡電話:(02)23123456 ext 288248
  • E-mail:hmsu1203@ntu.edu.tw

內分泌及營養學

  本實驗室研究營養與內分泌對認知科學(cognitive science)和乳癌(breast cancer)的影響。主要探討脂質代謝(lipid metabolism)、固醇類賀爾蒙(steroid hormone)如雌激素(estrogen)或糖皮質素(glucocorticoid)及神經傳導物質(neuron transmitters)在發育和老化大腦及乳癌生成扮演角色。

研究主題:

  1. 探討脂肪酸生合成及嵌入神經細胞膜磷脂質,進而影響神經細胞型態及功能之可能作用機制。
  2. 探討發育及老化腦區中脂質代謝、類固醇或神經傳導物質是否影響動物學習記憶能力、焦慮、壓力、疼痛、運動等行為表現及其作用機制。
  3. 利用乳癌細胞及乳癌鼠,探討脂肪酸及參與脂質代謝相關酵素表現對乳癌細胞增生、轉移及能量代謝等之作用機制。

  期許本實驗室能為婦女的健康及老人疾病的預防能有所貢獻。

論文著述:

(A) 期刊論文

  • Chang PY, Chang SF,  Chang TY, Su HM, Lu SC. (2021) Synergistic effects of electronegative-LDL- and palmitic-acid-triggered IL-1β production in macrophages via LOX-1- and voltage-gated-potassium-channel-dependent pathways. J Nutr Biochem. 97, 108767
  • Hua MC, Su HM, Lai MW, Yao TC, Tsai MH, Liao SL, Lai SH, Huang JL. (2021) Palmitoleic and Dihomo-γ-Linolenic Acids Are Positively Associated With Abdominal Obesity and Increased Metabolic Risk in Children. Front Pediatr. 9, 628496
  • Chang PY, Chang SF,  Chang TY, Su HM, Lu SC. (2021) Synergistic effects of electronegative-LDL- and palmitic-acid-triggered IL-1β production in macrophages via LOX-1- and voltage-gated-potassium-channel-dependent pathways. J Nutr Biochem. 97, 108767
  • Hua MC, Su HM, Lai MW, Yao TC, Tsai MH, Liao SL, Lai SH, Huang JL. (2021) Palmitoleic and Dihomo-γ-Linolenic Acids Are Positively Associated With Abdominal Obesity and Increased Metabolic Risk in Children. Front Pediatr. 9, 628496
  • Hua MC, Su HM, Kuo ML, Chen CC, Yao TC, sai MH, Liao SL, Lai SH, Chiu CY, Su KW, Chen LC, Yeh KW, Huang JL. (2019) Association of maternal allergy with human milk soluble CD14 and fatty acids, and early childhood atopic dermatitis. Peditar Allergy Immu. 30:204-213
  • Hsiao WT, Su HM, Su KP, Chen SH, Wu HP, You YL, Fu RH and Chao PM. (2019) Deficiency or activation of peroxisome proliferator-activated receptor α reduces the tissue concentrations of endogenously synthesized docosahexaenoic acid in C57BL/6J mice. Nutr Res Pract. 13:286-294
  • Lin YH, Chen CM, Su HM, Mu SC, Chang ML, Chu PY and Li SC. (2019) Association between postpartum nutritional status and postpartum depression symptoms. Nutritients. 11:1024
  • Hua MC, Su HM, Kuo ML, Chen CC, Yao TC, sai MH, Liao SL, Lai SH, Chiu CY, Su KW, Chen LC, Yeh KW, Huang JL. (2019) Association of maternal allergy with human milk soluble CD14 and fatty acids, and early childhood atopic dermatitis. Peditar Allergy Immu. 30:204-213
  • Hsiao WT, Su HM, Su KP, Chen SH, Wu HP, You YL, Fu RH and Chao PM. (2019) Deficiency or activation of peroxisome proliferator-activated receptor α reduces the tissue concentrations of endogenously synthesized docosahexaenoic acid in C57BL/6J mice. Nutr Res Pract. 13:286-294
  • Lin YH, Chen CM, Su HM, Mu SC, Chang ML, Chu PY and Li SC. (2019) Association between postpartum nutritional status and postpartum depression symptoms. Nutritients. 11:1024
  • Hua MC, Su HM, Yao TC, Kuo ML, Lai MW, Tsai MH, Huang JL. (2017) Alternation of plasma fatty acids composition and desaturase activities in children with liver steatosis. PloS one. 12:e0182277
  • Huang LH, Chung HY and Su HM. (2017) Docosahexaenoic acid reduces sterol regulatory element binding protein-1 and fatty acid synthase expression and inhibits cell proliferation by inhibiting pAkt signaling in a human breast cancer MCF-7 cell line. Bmc Cancer. 17:890-900
  • Hua MC, Su HM, Yao TC, Kuo ML, Lai MW, Tsai MH, Huang JL. (2017) Alternation of plasma fatty acids composition and desaturase activities in children with liver steatosis. PloS one. 12:e0182277
  • Huang LH, Chung HY and Su HM. (2017) Docosahexaenoic acid reduces sterol regulatory element binding protein-1 and fatty acid synthase expression and inhibits cell proliferation by inhibiting pAkt signaling in a human breast cancer MCF-7 cell line. Bmc Cancer. 17:890-900
  • Chen GC, Su HM, Lin YS, Tsou PY, Chyuan JH Chao PM. (2016) A conjugated fatty acid present at high levels in bitter melon seed favorably affects lipid metabolism in hepatocytes by increasing NAD(+)/NADH ratio and activating PPARα, AMPK and SIRT1 signaling pathway. The Journal of Nutritional Biochemistry 33:28-35
  • Teng CF, Hsieh WC, Yang CW, Su HM, Tsai TF, Sung WC, Hunag W, Su IJ. (2015) A Biphasic Response Pattern of Lipid Metabolomics in the Stage Progression of Hepatitis B Virus X Tumorigenesis. Molecular Carcinogenesis, 55:105-114.
  • Wu MT, Su HM, Cui Y, Windust A, Chou HN, Huang CJ. (2015) Fucoxanthin Enhances Chain Elongation and Desaturation of Alpha-Linolenic Acid in HepG2 Cells, Lipids, 50:945-953
  • Weylandt K, Serini S, Chen Y, Su HM, Lim K, Cittadini A, and Calviello G. (2015) Omega-3 Polyunsaturated Fatty Acids: The Way Forward in Times of Mixed Evidence, Biomed Research International. 143109
  • Su HM, Hsieh YT, Pan WH. (2014) Comparison of Plasma Trans-Fatty Acid, Docosahexaenoic Acid and Palmitoleic Acid Levels with Respect to Gender, Age and Area of Residence in Adult Taiwanese. 39:1-10.
  • Calviello G, Su HM, Weylandt KH, Fasano E, Serini S, and Cittadini A (2013) Experimental evidence of w-3 polyunsaturated fatty acid modulation of inflammatory cytokines and bioactive lipid mediators: their Potential Role in inflammatory, neurodegenerative, and neoplastic Diseases. BioMed Research International (accepted);
  • Chen HF (陳鏏仹) and Su HM* (2013) Exposure to a maternal n-3 fatty acid-deficient diet during brain development provokes excessive hypothalamic-pituitary-adrenal axis responses to stress and behavioral indices of depression and anxiety in male rat offspring later in life. Journal of Nutritional Biochemistry, 24:70-80
  • Chen HF (陳鏏仹) and Su HM* (2012) Fish oil supplementation of maternal rats on an n-3 fatty acid-deficient diet prevents depletion of maternal brain regional docosahexaenoic acid levels and has a postpartum anxiolytic effect. Journal of Nutritional Biochemistry, (In press)
  • Su HM*, Hsieh PH(謝佩璇), and Chen HF (2010) A maternal high n-6 fat diet with fish oil supplementation during pregnancy and lactation in rats decreases breast cancer risk in the female offspring. Journal of Nutritional Biochemistry, 21:1033-1037
  • Su HM* (2010) Mechanisms of n-3 fatty acid-mediated development and maintenance of learning memory performance. Journal of Nutritional Biochemistry, 21:364-373
  • Lu IF(呂怡芬), Hasio AC, Hu MC, Yang FM and Su HM* (2010) Docosahexaenoic acid induces proteasome-dependent degradation of estrogen receptor a and inhibits the downstream signaling target in MCF-7 breast cancer cells. Journal of Nutritional Biochemistry, 21:512-517.
  • Wang PY(王寶源), Chen JJ, and Su HM* (2010)Docosahexaenoic acid supplementation of primary rat hippocampal neurons attenuates the neurotoxicity induced by aggregated amyloid beta protein42 and upregulates cytoskeletal protein expression. Journal of Nutritional Biochemistry, 21:345-350.
  • Lo CY (駱中郁), Hsieh PH, Chen HF and Su HM* (2009) Maternal high fat diet during pregnancy in rats results in a greater risk of carcinogen-induced mammary tumors in female offspring than high fat intake in postnatal life.International Journal of Cancer, 125:767-773.
  • Chung WL(鍾宛伶), Chen JJ, and Su HM* (2008) Fish oil supplementation of control and (n-3) fatty acid-deficient male rats enhances reference and working memory performance and increases brain regional docosahexaenoic acid levels. Journal of Nutrition. 138:1165-1171.
  • Hasio AC(蕭安哲), Chen JJ, Chung WL and Su HM*. (2008) Effect of Brain DHA levels on cytoskeleton expression. Asia Pacific Journal of Clinical Nutrition, 17:158-161.
  • Su HM*, Faust PL, Moser AB, Moser HW, Watkins PA. (2003) Docosahexaenoic acid synthesis and transport in peroxisomal disorders studied in vivo & in vitro. In book of Essential Fatty Acids and Eicosanoids: Invited papers from the Fifth International Congress. American Oil Chemistry Society.
  • Su HM*, Moser AB, Moser HW, Watkins PA. (2001) Peroxisomal straight-chain acyl-coA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesis. Journal of Biological Chemistry. 276:38115-20.
  • Faust PL, Su HM, Moser A, Moser HW.(2001) The peroxisome deficient PEX2 Zellweger mouse: pathologic and biochemical correlates of lipid dysfunction. Journal of Molecular Neuroscience. 16:289-97
  • Su HM, Huang MC, Saad NM, Nathanielsz PW, Brenna JT. (2001) Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study. Journal of Lipid Research. 42:581-6.
  • Su HM, Corso TN, Nathanielsz PW, Brenna JT. (1999) Linoleic acid kinetics and conversion to arachidonic acid in the pregnant and fetal baboon. Journal of Lipid Research. 40:1304-12.
  • Su HM, Bernardo L, Mirmiran M, Ma XH, Corso TN, Nathanielsz PW, Brenna JT. (1999) Bioequivalence of dietary alpha-linolenic and docosahexaenoic acids as sources of docosahexaenoate accretion in brain and associated organs of neonatal baboons. Pediatric Research. 45:87-93.
  • Su HM, Bernardo L, Mirmiran M, Ma XH, Nathanielsz PW, Brenna JT. (1999) Dietary 18:3n-3 and 22:6n-3 as sources of 22:6n-3 accretion in neonatal baboon brain and associated organs. Lipids. 34:S347-50.
  • Su HM, Brenna JT.(1998) Simultaneous measurement of desaturase activities using stable isotope tracers or a nontracer method. Analytical Biochemistry. 261:43-50.
  • Su HM, Keswick LA, Brenna JT. (1996) Increasing dietary linoleic acid in young rats increases and then decreases docosahexaenoic acid in retina but not in brain. Lipids. 31:1289-98.
  • Sheaff RC, Su HM, Keswick LA, Brenna JT. (1995) Conversion of alpha-linolenate to docosahexaenoate is not depressed by high dietary levels of linoleate in young rats: tracer evidence using high precision mass spectrometry. Journal of Lipid Research. 36:998-1008.

Su, Hui-Min
Ph.D., Cornell
Associate Professor
Phone:+886-2-23123456-ext 88248
E-mail: hmsu1203@ntu.edu.tw


Research Experiences & Education:
2001-2010
Assistant Professor, Physiology, College of Medicine, National Taiwan University
1998-2001
Research Associate, Neurogenetics Research Center, Kennedy Krieger Institute, Neurology, School of Medicine, Johns Hopkins University
1998
Ph. D. Nutritional Sciences, Cornell University
1995
M.S. Nutritional Sciences, Cornell University
1990
B.S. Agriculture Chemistry, National Taiwan University


Research area:
Our research area has been focusing on the fatty acids and estrogen on breast cancer and Alzheimer’s disease (AD). The goal is to identify a nature supplementation, fish oil enriched in docosahexaenoic acid (DHA, 22:6n-3) on the prevention of both Alzheimer’s disease and breast cancer. We hypothesized that timing, but not the duration, of n-3 fatty acids supplementation is critical for reducing both breast cancer risk and age-related memory decline, and that n-3 fatty acids supplementation during gestation and lactation would have a greater benefit on the prevention of both diseases.
Currently, we study the mechanism of n-6 and n-3 fatty acids on nongenomic estrogen receptor a signaling and nuclear factor kappaB activation in drug-resistant human breast cancer cell line MCF-7. We will extend our study to evaluate whether a maternal n-3 fatty acid-deficient diet during pregnancy and lactation regulates the hypothalamic-pituitary-adrenal (HPA) axis response, regulation, and epigenetic changes leading to anxiety- and depression-like behaviors in postpartum rats and in the offspring later in life.


Publications

  1. Chen GC, Su HM, Lin YS, Tsou PY, Chyuan JH Chao PM. (2016) A conjugated fatty acid present at high levels in bitter melon seed favorably affects lipid metabolism in hepatocytes by increasing NAD(+)/NADH ratio and activating PPARα, AMPK and SIRT1 signaling pathway. The Journal of Nutritional Biochemistry 33:28-35
  2. Teng CF, Hsieh WC, Yang CW, Su HM, Tsai TF, Sung WC, Hunag W, Su IJ. (2015) A Biphasic Response Pattern of Lipid Metabolomics in the Stage Progression of Hepatitis B Virus X Tumorigenesis. Molecular Carcinogenesis, 55:105-114.
  3. Wu MT, Su HM, Cui Y, Windust A, Chou HN, Huang CJ. (2015) Fucoxanthin Enhances Chain Elongation and Desaturation of Alpha-Linolenic Acid in HepG2 Cells, Lipids, 50:945-953
  4. Weylandt K, Serini S, Chen Y, Su HM, Lim K, Cittadini A, and Calviello G. (2015) Omega-3 Polyunsaturated Fatty Acids: The Way Forward in Times of Mixed Evidence, Biomed Research International. 143109
  5. Su HM, Hsieh YT, Pan WH. (2014) Comparison of Plasma Trans-Fatty Acid, Docosahexaenoic Acid and Palmitoleic Acid Levels with Respect to Gender, Age and Area of Residence in Adult Taiwanese. 39:1-10.
  6. Calviello G, Su HM, Weylandt KH, Fasano E, Serini S, and Cittadini A (2013) Experimental evidence of w-3 polyunsaturated fatty acid modulation of inflammatory cytokines and bioactive lipid mediators: their Potential Role in inflammatory, neurodegenerative, and neoplastic Diseases. BioMed Research International (accepted);
  7. Chen HF (陳鏏仹) and Su HM* (2013) Exposure to a maternal n-3 fatty acid-deficient diet during brain development provokes excessive hypothalamic-pituitary-adrenal axis responses to stress and behavioral indices of depression and anxiety in male rat offspring later in life. Journal of Nutritional Biochemistry, 24:70-80
  8. Chen HF (陳鏏仹) and Su HM* (2012) Fish oil supplementation of maternal rats on an n-3 fatty acid-deficient diet prevents depletion of maternal brain regional docosahexaenoic acid levels and has a postpartum anxiolytic effect. Journal of Nutritional Biochemistry, (In press)
  9. Su HM*, Hsieh PH(謝佩璇), and Chen HF (2010) A maternal high n-6 fat diet with fish oil supplementation during pregnancy and lactation in rats decreases breast cancer risk in the female offspring. Journal of Nutritional Biochemistry, 21:1033-1037
  10. Su HM* (2010) Mechanisms of n-3 fatty acid-mediated development and maintenance of learning memory performance. Journal of Nutritional Biochemistry, 21:364-373
  11. Lu IF(呂怡芬), Hasio AC, Hu MC, Yang FM and Su HM* (2010) Docosahexaenoic acid induces proteasome-dependent degradation of estrogen receptor a and inhibits the downstream signaling target in MCF-7 breast cancer cells. Journal of Nutritional Biochemistry, 21:512-517.
  12. Wang PY(王寶源), Chen JJ, and Su HM* (2010)Docosahexaenoic acid supplementation of primary rat hippocampal neurons attenuates the neurotoxicity induced by aggregated amyloid beta protein42 and upregulates cytoskeletal protein expression. Journal of Nutritional Biochemistry, 21:345-350.
  13. Lo CY (駱中郁), Hsieh PH, Chen HF and Su HM* (2009) Maternal high fat diet during pregnancy in rats results in a greater risk of carcinogen-induced mammary tumors in female offspring than high fat intake in postnatal life.International Journal of Cancer, 125:767-773.
  14. Chung WL(鍾宛伶), Chen JJ, and Su HM* (2008) Fish oil supplementation of control and (n-3) fatty acid-deficient male rats enhances reference and working memory performance and increases brain regional docosahexaenoic acid levels. Journal of Nutrition. 138:1165-1171.
  15. Hasio AC(蕭安哲), Chen JJ, Chung WL and Su HM*. (2008) Effect of Brain DHA levels on cytoskeleton expression. Asia Pacific Journal of Clinical Nutrition, 17:158-161.
  16. Su HM*, Faust PL, Moser AB, Moser HW, Watkins PA. (2003) Docosahexaenoic acid synthesis and transport in peroxisomal disorders studied in vivo & in vitro. In book of Essential Fatty Acids and Eicosanoids: Invited papers from the Fifth International Congress. American Oil Chemistry Society.
  17. Su HM*, Moser AB, Moser HW, Watkins PA. (2001) Peroxisomal straight-chain acyl-coA oxidase and D-bifunctional protein are essential for the retroconversion step in docosahexaenoic acid synthesis. Journal of Biological Chemistry. 276:38115-20.
  18. Faust PL, Su HM, Moser A, Moser HW.(2001) The peroxisome deficient PEX2 Zellweger mouse: pathologic and biochemical correlates of lipid dysfunction. Journal of Molecular Neuroscience. 16:289-97
  19. Su HM, Huang MC, Saad NM, Nathanielsz PW, Brenna JT. (2001) Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study. Journal of Lipid Research. 42:581-6.
  20. Su HM, Corso TN, Nathanielsz PW, Brenna JT. (1999) Linoleic acid kinetics and conversion to arachidonic acid in the pregnant and fetal baboon. Journal of Lipid Research. 40:1304-12.
  21. Su HM, Bernardo L, Mirmiran M, Ma XH, Corso TN, Nathanielsz PW, Brenna JT. (1999) Bioequivalence of dietary alpha-linolenic and docosahexaenoic acids as sources of docosahexaenoate accretion in brain and associated organs of neonatal baboons. Pediatric Research. 45:87-93.
  22. Su HM, Bernardo L, Mirmiran M, Ma XH, Nathanielsz PW, Brenna JT. (1999) Dietary 18:3n-3 and 22:6n-3 as sources of 22:6n-3 accretion in neonatal baboon brain and associated organs. Lipids. 34:S347-50.
  23. Su HM, Brenna JT.(1998) Simultaneous measurement of desaturase activities using stable isotope tracers or a nontracer method. Analytical Biochemistry. 261:43-50.
  24. Su HM, Keswick LA, Brenna JT. (1996) Increasing dietary linoleic acid in young rats increases and then decreases docosahexaenoic acid in retina but not in brain. Lipids. 31:1289-98.
  25. Sheaff RC, Su HM, Keswick LA, Brenna JT. (1995) Conversion of alpha-linolenate to docosahexaenoate is not depressed by high dietary levels of linoleate in young rats: tracer evidence using high precision mass spectrometry. Journal of Lipid Research. 36:998-1008.

碩士班學生

賴芊嬡
顏芷茜