成員簡介

陳朝峰名譽教授

陳朝峰名譽教授

  • 陳朝峰

  • 職  稱：名譽教授
  • 學  歷：英國安南普敦大學 博士
  • 專  長：腎臟生理學
  • 聯絡電話：(02)23123456 ext 88232
  • E-mail：chfochen@ntu.edu.tw

腎臟生理學

本實驗室主要的研究工作是研究缺氧與腎臟生理。

目前主要的研究方向有：

(1)血行動力與腎臟功能的關係

(2)神經系統與腎功能的關係

(3)缺氧預處理的保護機制

(4)視網膜神經細胞的保護機制。

PUBLICATIONS

  1. Tu YP, Chen SC, Liu YH, Chen CF, Hour TC. Postconditioning with far-infrared irradiation increases heme oxygenase-1 expression and protects against ischemia/reperfusion injury in rat testis. Life Sci. 2013 Jan 17;92(1):35-41.
  2. Lu YZ, Wu CC, Huang YC, Huang CY, Yang CY, Lee TC, Chen CF, Yu LC. Neutrophil priming by hypoxic preconditioning protects against epithelial barrier damage and enteric bacterial translocation in intestinal ischemia/reperfusion. Lab Invest. 2012 May;92(5):783-96.
  3. Chen YC, Lai LC, Tu YP, Wu SD, Chen CF, Li B. Far infrared ray irradiation attenuates apoptosis and cell death of cultured keratinocytes stressed by dehydration. J Photochem Photobiol B. 2012 Jan 5;106:61-8.
  4. Tu YP, Chuang SJ, Chen SC, Liu YH, Chen CF, Hour TC. Simvastatin induces the expression of hemeoxygenase-1 against ischemia-reperfusion injury on the testes in rats. Toxicol Lett. 2011 Dec 15;207(3):242-50.
  5. Ko ML, Chen CF, Peng PH, Peng YH. Simvastatin upregulates Bcl-2 expression and protects retinal neurons from early ischemia/reperfusion injury in the rat retina. Exp Eye Res. 2011 Nov;93(5):580-5.
  6. Peng PH, Chao HM, Juan SH, Chen CF, Liu JH, Ko ML. Pharmacological preconditioning by low dose cobalt protoporphyrin induces heme oxygenase-1 overexpression and alleviates retinal ischemia-reperfusion injury in rats. Curr Eye Res. 2011 Mar;36(3):238-46.
  7. Hsu HH, Ruan T, Ko WJ, Hsu JY, Chen JS, Lee YC, Lai IR, Chen CF. Effects of simvastatin on pulmonary C-fiber sensitivity in rats with monocrotaline-induced pulmonary hypertension. J Heart Lung Transplant. 2011 Mar;30(3):332-40.
  8. Ko ML, Peng PH, Hsu SY, Chen CF. Dietary deficiency of vitamin E aggravates retinal ganglion cell death in experimental glaucoma of rats. Curr Eye Res. 2010 Sep;35(9):842-9.
  9. Chiang CY, Tsai CP, Chen CF, Chou TF. Reduction of hexa(sulfobutyl)fullerence on oxidative injury by xanthine and xanthine oxidase in isolated rat lungs. Chin J Physiol. 2009 Nov 30;52(5 Suppl):406-10.
  10. Chou TF, Ma MC, Tsai CP, Chen CF. Enhancement of superoxide dismutase activity in rat lungs after hypoxic preconditioning. Chin J Physiol. 2009 Nov 30;52(5 Suppl):376-83.
  11. Wu MS, Chien CT, Ma MC, Chen CF. Protection of ischemic preconditioning on renal neural function in rats with acute renal failure.Chin J Physiol. 2009 Nov 30;52(5 Suppl):365-75.
  12. Peng PH, Chiou LF, Chao HM, Lin S, Chen CF, Liu JH, Ko ML. Effects of epigallocatechin-3-gallate on rat retinal ganglion cells after optic nerve axotomy. Exp Eye Res. 2010 Apr;90(4):528-34.
  13. Cheng CK, Peng PH, Tien LT, Cai YJ, Chen CF, Lee YJ. Bevacizumab is not toxic to retinal ganglion cells after repeated intravitreal injection.Retina.2009 Mar;29(3):306-12.
  14. Hsu HH, Ko WJ, Hsu JY, Chen JS, Lee YC, Lai IR, Chen* CF. Simvastatin ameliorates established pulmonary hypertension through a heme oxygenase-1 dependent pathway in rats. Respir Res. 2009 ;10:32-44.
  15. Lin BR, Yu CJ, Chen WC, Lee HS, Chang HM, Lee YC, Chien CT, Chen CF . Green tea extract supplement reduces D-galactosamine-induced acute liver injury by inhibition of apoptotic and proinflammatory signaling.J Biomed Sci. 2009;16:35-42
  16. Chou TF, Ma MC, Tsai CP, Chen CF. (2009) Enhancement of Superoxide Dismutase Activity in Rat Lungs after Hypoxic Preconditioning. Chin J Physiol. 2009 Nov 30;52(5 Suppl):376-83.
  17. Wu MS, Chien CT, Ma MC, Chen CF.Protection of ischemic preconditioning on renal neural function in rats with acute renal failure.Chin J Physiol. 2009 Nov 30;52(5 Suppl):365-75.
  18. Chiang CY, Tsai CP, Chen CF, Chou TF.Reduction of hexa(sulfobutyl)fullerence on oxidative injury by xanthine and xanthine oxidase in isolated rat lungs. Chin J Physiol. 2009 Nov 30;52(5 Suppl):406-10.
  19. Lai IR, Chang KJ, Tsai HW, Chen* CF.  (2008) Pharmacological Preconditioning with Simvastatin Protects Liver from Ischemia-Reperfusion Injury by Heme Oxygenase-1 Induction. Transplantation. 85: 732–738.
  20. Peng PH, Ko ML, Chen* CF. (2008) Epigallocatechin-3-gallate reduces retinal ischemia/reperfusion injury by attenuating neuronal nitric oxide synthase expression and activity. Exp Eye Res. 86(4):637-46.
  21. Yang CC, Chien CT, Wu MH, Ma MC, Chen* CF. (2008) NMDA Receptor Blocker Ameliorates Ischemia/Reperfusion-Induced Renal Dysfunction in Rat Kidneys. Am J Physiol Renal Physiol. 294(6):F1433-40
  22. Peng PH, Ko ML, Chen CF, Juan SH. (2008) Heme oxygenase-1 gene transfer protects retinal ganglion cells from ischemia-reperfusion injury. Clin Sci (Lond). 115(11):335-42.
  23. Chan KC, Lin CJ, Lee PH, Chen CF, Lai YL, Sun WZ, Cheng YJ. (2008) Propofol attenuates the decrease of dynamic compliance and water content in the lung by decreasing oxidative radicals released from the reperfused liver.Anesth Analg. 107(4):1284-9.
  24. Lin BR, Hsieh HT, Lee JM, Lai IR, Chen CF, Yu LC. (2008) Luminal hydrochloric acid stimulates rapid transepithelial ion fluxes in rodent esophageal stratified squamous epithelium. J Physiol Pharmacol. 59(3):525-42
  25. Cheng CK, Peng PH, Tien LT, Cai YJ, Chen CF, Lee YJ. Bevacizumab is not toxic to retinal ganglion cells after repeated intravitreal injection. Retina. 2008 Dec 2. [Epub ahead of print]
  26. Yang CC, Ma MC, Chien CT, Chen CF. (2007) Hypoxic Preconditioning attenuates lipopolysaccharide-induced oxidative stress in rat kidneys. J Physiol. 582(Pt 1):407-19
  27. Wann JG, Hsu YH, Yang CC, Lin CS, Tai DW, Chen JS, Hsiao CW, Chen CF. (2007) Neutrophils in acidotic haemodialysed patients have lower intracellular pH and inflamed state. Nephrol Dial Transplant. 22(9):2613-22
  28. Chan CY, Chen YS, Ma MC, Chen CF. (2007) Remodeling of experimental arteriovenous fistula with increased matrix metalloproteinase expression in rats. J Vasc Surg. 45(4):804-11.
  29. Chan CY, Chen YS, Lee HH, Huang HS, Lai YL, Chen CF, Ma MC. (2007)  Erythropoietin protects post-ischemic hearts by preventing extracellular matrix degradation: Role of Jak2-ERK pathway. Life Sci. 81(9):717-23.
  30. Lai IR, Chang KJ, Chen CF. (2007) The mechanism of hepatic heme oxygenase-1 expression by limb remote ischemic preconditioning. Transplantation 83:364
  31. Wann JG, Yang CC, Chang LC, Hsu YH, Chien CT, Tai DW, Chen JS, Lin CS, Chen CF. (2006) Enhanced Expression of Glucose Transporter 1 on Erythrocyte Membrane in Hemodialysis Patients: The Possible Role in Erythrocyte Ascorbate Recycling. Am J Kidney Dis. 47:1055-63.
  32. Lai IR, Chang KJ, Chen CF, Tsai HW. (2006) Transient limb Ischemia Induces Remote Preconditioning in Liver among rats：The Protective Role of Heme Oxygenase-1. Transplantation 81:1311-1317.
  33. Huang HS, Ma MC, Chen J, and Chen CF. (2006) Vitamin E attenuates crystal formation in rat kidneys: roles of renal tubular cell death and crystallization inhibitors. Kidney Int. 70:699-710.
  34. Huang HS, Ma MC, Chen J, and Chen CF. (2006) Changes in the nitric oxide production in the rat kidney due to CaOx nephrolithiasis. Neurourol Urodyn. 25:252-8.
  35. Chang AY, Wang CH, Chiu TH, Chi JW, Chen CF, Ho LT, Lin AM. (2005) Hypoxic preconditioning attenuated in kainic acid-induced neurotoxicity in rat hippocampus. Exp Neurol. 195:40-48.
  36. Ko ML , Peng PH, Ma MC, Ritch R, Chen CF. (2005) Dynamic Changes of Reactive Oxygen Species and Antioxidants Levels on Retinas in Experimental Glaucoma. Free Radic Biol Med. 39:365-73.
  37. Chen YS, Chien CT, Ma MC, Tseng YZ, Lin FY, Wang SS, Chen CF. (2005) Protection "Outside the Box" (Skeletal Remote Preconditioning) in Rat Model is Triggered by Free Radical Pathway. J Surg Res. 126:92-101.
  38. Lai IR, Ma MC, Chen CF and KJ Chang. (2004) The protective role of heme oxgenase-1 on liver after hypoxic preconditioning in rats. Transplantation 77:1004-8.
  39. Yu HJ, Chien CT, Lai YJ, Lai MK, Chen CF, Levin RM, Hsu SM. (2004) Hypoxia preconditioning attenuates bladder overdistension-induced oxidative injury by upregulation of bcl-2 in the rat. J Physiol. 554:815-828.
  40. Huang HS, Chen CF, Chen J. (2003) Lipid peroxidation and its correlations with urinary levels of oxalate, citric acid, and osteopontin in patients with renal calcium oxalate stones. Urology 62:1123-8.
  41. Chen CF, Su-Yi Tsai, Ming-Chieh Ma, and Ming-Shiou Wu. (2003) Hypoxic preconditioning enhances renal superoxide dismutase in rats. J  Physiol. 552:561-569.
  42. Cheng YJ, Chien CT, Wang YP, Fu TC, Chen TL, Chen CF. (2003) Fluid administration prevents renal dysfunction during hypotension under spinal anesthesia in a rat model. Acta Anaesthesiol Sin. 41(1):7-12.
  43. Lin AM, Dung SW, Chen CF, Chen WH, Ho LT. (2003) Hypoxic preconditioning prevents cortical infarction by transient focal ischemia-reperfusion. Ann N Y Acad Sci. 993:168-78.
  44. Cheng YJ, Chien CT and Chen CF. (2003) Oxidative stress in bilateral total knee replacement using tourniquet. J Bone Joint Surg Br. 85:679-682.
  45. Lai IR, Ma MC, Chen CF and KJ Chang. (2003) The effect of an intestinal ischemia-reperfusion injury upon renal nerve activity among rats. Shock 19:481-486.
  46. Huang HS, Ma MC, Chen J, and Chen CF. (2003) Changes in renal hemodynamics and urodynamics in rats with chronic hyperoxaluria and after acute oxalate infusion: role of free radicals. Neurourol Urodyn. 22(2):176-82.

2003-2013

  1. Tu YP, Chen SC, Liu YH, Chen CF, Hour TC. Postconditioning with far-infrared irradiation increases heme oxygenase-1 expression and protects against ischemia/reperfusion injury in rat testis. Life Sci. 2013 Jan 17;92(1):35-41.
  2. Lu YZ, Wu CC, Huang YC, Huang CY, Yang CY, Lee TC, Chen CF, Yu LC. Neutrophil priming by hypoxic preconditioning protects against epithelial barrier damage and enteric bacterial translocation in intestinal ischemia/reperfusion. Lab Invest. 2012 May;92(5):783-96.
  3. Chen YC, Lai LC, Tu YP, Wu SD, Chen CF, Li B. Far infrared ray irradiation attenuates apoptosis and cell death of cultured keratinocytes stressed by dehydration. J Photochem Photobiol B. 2012 Jan 5;106:61-8.
  4. Tu YP, Chuang SJ, Chen SC, Liu YH, Chen CF, Hour TC. Simvastatin induces the expression of hemeoxygenase-1 against ischemia-reperfusion injury on the testes in rats. Toxicol Lett. 2011 Dec 15;207(3):242-50.
  5. Ko ML, Chen CF, Peng PH, Peng YH. Simvastatin upregulates Bcl-2 expression and protects retinal neurons from early ischemia/reperfusion injury in the rat retina. Exp Eye Res. 2011 Nov;93(5):580-5.
  6. Peng PH, Chao HM, Juan SH, Chen CF, Liu JH, Ko ML. Pharmacological preconditioning by low dose cobalt protoporphyrin induces heme oxygenase-1 overexpression and alleviates retinal ischemia-reperfusion injury in rats. Curr Eye Res. 2011 Mar;36(3):238-46.
  7. Hsu HH, Ruan T, Ko WJ, Hsu JY, Chen JS, Lee YC, Lai IR, Chen CF. Effects of simvastatin on pulmonary C-fiber sensitivity in rats with monocrotaline-induced pulmonary hypertension. J Heart Lung Transplant. 2011 Mar;30(3):332-40.
  8. Ko ML, Peng PH, Hsu SY, Chen CF. Dietary deficiency of vitamin E aggravates retinal ganglion cell death in experimental glaucoma of rats. Curr Eye Res. 2010 Sep;35(9):842-9.
  9. Chiang CY, Tsai CP, Chen CF, Chou TF. Reduction of hexa(sulfobutyl)fullerence on oxidative injury by xanthine and xanthine oxidase in isolated rat lungs. Chin J Physiol. 2009 Nov 30;52(5 Suppl):406-10.
  10. Chou TF, Ma MC, Tsai CP, Chen CF. Enhancement of superoxide dismutase activity in rat lungs after hypoxic preconditioning. Chin J Physiol. 2009 Nov 30;52(5 Suppl):376-83.
  11. Wu MS, Chien CT, Ma MC, Chen CF. Protection of ischemic preconditioning on renal neural function in rats with acute renal failure.Chin J Physiol. 2009 Nov 30;52(5 Suppl):365-75.
  12. Peng PH, Chiou LF, Chao HM, Lin S, Chen CF, Liu JH, Ko ML. Effects of epigallocatechin-3-gallate on rat retinal ganglion cells after optic nerve axotomy. Exp Eye Res. 2010 Apr;90(4):528-34.
  13. Cheng CK, Peng PH, Tien LT, Cai YJ, Chen CF, Lee YJ.
  14. Cheng CK, Peng PH, Tien LT, Cai YJ, Chen CF, Lee YJ. Bevacizumab is not toxic to retinal ganglion cells after repeated intravitreal injection.Retina.2009 Mar;29(3):306-12.
  15. Hsu HH, Ko WJ, Hsu JY, Chen JS, Lee YC, Lai IR, Chen* CF. Simvastatin ameliorates established pulmonary hypertension through a heme oxygenase-1 dependent pathway in rats. Respir Res. 2009 ;10:32-44.
  16. Lin BR, Yu CJ, Chen WC, Lee HS, Chang HM, Lee YC, Chien CT, Chen CF . Green tea extract supplement reduces D-galactosamine-induced acute liver injury by inhibition of apoptotic and proinflammatory signaling.J Biomed Sci. 2009;16:35-42
  17. Chou TF, Ma MC, Tsai CP, Chen CF. (2009) Enhancement of Superoxide Dismutase Activity in Rat Lungs after Hypoxic Preconditioning. Chin J Physiol. 2009 Nov 30;52(5 Suppl):376-83.
  18. Wu MS, Chien CT, Ma MC, Chen CF.Protection of ischemic preconditioning on renal neural function in rats with acute renal failure.Chin J Physiol. 2009 Nov 30;52(5 Suppl):365-75.
  19. Chiang CY, Tsai CP, Chen CF, Chou TF.Reduction of hexa(sulfobutyl)fullerence on oxidative injury by xanthine and xanthine oxidase in isolated rat lungs. Chin J Physiol. 2009 Nov 30;52(5 Suppl):406-10.
  20. Lai IR, Chang KJ, Tsai HW, Chen* CF.  (2008) Pharmacological Preconditioning with Simvastatin Protects Liver from Ischemia-Reperfusion Injury by Heme Oxygenase-1 Induction. Transplantation. 85: 732–738.
  21. Peng PH, Ko ML, Chen* CF. (2008) Epigallocatechin-3-gallate reduces retinal ischemia/reperfusion injury by attenuating neuronal nitric oxide synthase expression and activity. Exp Eye Res. 86(4):637-46.
  22. Yang CC, Chien CT, Wu MH, Ma MC, Chen* CF. (2008) NMDA Receptor Blocker Ameliorates Ischemia/Reperfusion-Induced Renal Dysfunction in Rat Kidneys. Am J Physiol Renal Physiol. 294(6):F1433-40
  23. Peng PH, Ko ML, Chen CF, Juan SH. (2008) Heme oxygenase-1 gene transfer protects retinal ganglion cells from ischemia-reperfusion injury. Clin Sci (Lond). 115(11):335-42.
  24. Chan KC, Lin CJ, Lee PH, Chen CF, Lai YL, Sun WZ, Cheng YJ. (2008) Propofol attenuates the decrease of dynamic compliance and water content in the lung by decreasing oxidative radicals released from the reperfused liver.Anesth Analg. 107(4):1284-9.
  25. Lin BR, Hsieh HT, Lee JM, Lai IR, Chen CF, Yu LC. (2008) Luminal hydrochloric acid stimulates rapid transepithelial ion fluxes in rodent esophageal stratified squamous epithelium. J Physiol Pharmacol. 59(3):525-42
  26. Cheng CK, Peng PH, Tien LT, Cai YJ, Chen CF, Lee YJ. Bevacizumab is not toxic to retinal ganglion cells after repeated intravitreal injection. Retina. 2008 Dec 2. [Epub ahead of print]
  27. Yang CC, Ma MC, Chien CT, Chen CF. (2007) Hypoxic Preconditioning attenuates lipopolysaccharide-induced oxidative stress in rat kidneys. J Physiol. 582(Pt 1):407-19
  28. Wann JG, Hsu YH, Yang CC, Lin CS, Tai DW, Chen JS, Hsiao CW, Chen CF. (2007) Neutrophils in acidotic haemodialysed patients have lower intracellular pH and inflamed state. Nephrol Dial Transplant. 22(9):2613-22
  29. Chan CY, Chen YS, Ma MC, Chen CF. (2007) Remodeling of experimental arteriovenous fistula with increased matrix metalloproteinase expression in rats. J Vasc Surg. 45(4):804-11.
  30. Chan CY, Chen YS, Lee HH, Huang HS, Lai YL, Chen CF, Ma MC. (2007)  Erythropoietin protects post-ischemic hearts by preventing extracellular matrix degradation: Role of Jak2-ERK pathway. Life Sci. 81(9):717-23.
  31. Lai IR, Chang KJ, Chen CF. (2007) The mechanism of hepatic heme oxygenase-1 expression by limb remote ischemic preconditioning. Transplantation 83:364
  32. Wann JG, Yang CC, Chang LC, Hsu YH, Chien CT, Tai DW, Chen JS, Lin CS, Chen CF. (2006) Enhanced Expression of Glucose Transporter 1 on Erythrocyte Membrane in Hemodialysis Patients: The Possible Role in Erythrocyte Ascorbate Recycling. Am J Kidney Dis. 47:1055-63.
  33. Lai IR, Chang KJ, Chen CF, Tsai HW. (2006) Transient limb Ischemia Induces Remote Preconditioning in Liver among rats：The Protective Role of Heme Oxygenase-1. Transplantation 81:1311-1317.
  34. Huang HS, Ma MC, Chen J, and Chen CF. (2006) Vitamin E attenuates crystal formation in rat kidneys: roles of renal tubular cell death and crystallization inhibitors. Kidney Int. 70:699-710.
  35. Huang HS, Ma MC, Chen J, and Chen CF. (2006) Changes in the nitric oxide production in the rat kidney due to CaOx nephrolithiasis. Neurourol Urodyn. 25:252-8.
  36. Chang AY, Wang CH, Chiu TH, Chi JW, Chen CF, Ho LT, Lin AM. (2005) Hypoxic preconditioning attenuated in kainic acid-induced neurotoxicity in rat hippocampus. Exp Neurol. 195:40-48.
  37. Ko ML , Peng PH, Ma MC, Ritch R, Chen CF. (2005) Dynamic Changes of Reactive Oxygen Species and Antioxidants Levels on Retinas in Experimental Glaucoma. Free Radic Biol Med. 39:365-73.
  38. Chen YS, Chien CT, Ma MC, Tseng YZ, Lin FY, Wang SS, Chen CF. (2005) Protection "Outside the Box" (Skeletal Remote Preconditioning) in Rat Model is Triggered by Free Radical Pathway. J Surg Res. 126:92-101.
  39. Lai IR, Ma MC, Chen CF and KJ Chang. (2004) The protective role of heme oxgenase-1 on liver after hypoxic preconditioning in rats. Transplantation 77:1004-8.
  40. Yu HJ, Chien CT, Lai YJ, Lai MK, Chen CF, Levin RM, Hsu SM. (2004) Hypoxia preconditioning attenuates bladder overdistension-induced oxidative injury by upregulation of bcl-2 in the rat. J Physiol. 554:815-828.
  41. Huang HS, Chen CF, Chen J. (2003) Lipid peroxidation and its correlations with urinary levels of oxalate, citric acid, and osteopontin in patients with renal calcium oxalate stones. Urology 62:1123-8.
  42. Chen CF, Su-Yi Tsai, Ming-Chieh Ma, and Ming-Shiou Wu. (2003) Hypoxic preconditioning enhances renal superoxide dismutase in rats. J  Physiol. 552:561-569.
  43. Cheng YJ, Chien CT, Wang YP, Fu TC, Chen TL, Chen CF. (2003) Fluid administration prevents renal dysfunction during hypotension under spinal anesthesia in a rat model. Acta Anaesthesiol Sin. 41(1):7-12.
  44. Lin AM, Dung SW, Chen CF, Chen WH, Ho LT. (2003) Hypoxic preconditioning prevents cortical infarction by transient focal ischemia-reperfusion. Ann N Y Acad Sci. 993:168-78.
  45. Cheng YJ, Chien CT and Chen CF. (2003) Oxidative stress in bilateral total knee replacement using tourniquet. J Bone Joint Surg Br. 85:679-682.
  46. Lai IR, Ma MC, Chen CF and KJ Chang. (2003) The effect of an intestinal ischemia-reperfusion injury upon renal nerve activity among rats. Shock 19:481-486.
  47. Huang HS, Ma MC, Chen J, and Chen CF. (2003) Changes in renal hemodynamics and urodynamics in rats with chronic hyperoxaluria and after acute oxalate infusion: role of free radicals. Neurourol Urodyn. 22(2):176-82.