成員簡介

湯志永教授

湯志永教授
  • 湯志永

  • 職  稱:教授
  • 學  歷:美國加州大學 洛杉磯分校 博士
  • 專  長:神經生理學
  • 聯絡電話:(02)2356-2215
  • E-mail:tang@ntu.edu.tw

神經生理學

  我的主要研究領域是離子通道(ion channel)神經生理學。離子通道是決定神經與肌肉細胞是否能正常運作的最基本及最重要因子之一。近年來,科學界逐漸了解,離子通道的異常是導致許多疾病發生的主因,這類疾病現在已經被通稱為離子通道疾病(channelopathy)。事實上,離子通道疾病的種類繁多,不只是神經肌肉系統,幾乎人體各主要器官系統都可能發生。例如:心血管系統的心率不整(long QT syndrome);內分泌系統的原發性醛固酮增多症(primary aldosteronism)、胰島素分泌異常(familial persistent hyperinsulinemic hypoglycemia of infancy);呼吸系統的纖維化囊腫(cystic fibrosis);腎臟系統的腎因性高血壓(Batter’s Syndrome and Liddle’s Syndrome);神經系統的動作失調(episodic ataxia and spinocerebellar ataxia)、腦白質退化症(leukodystrophy)、癲癇(benign familial neonatal epilepsy)、偏頭痛(familial hemiplegic migraine)、聽覺異常(non-syndromic deafness);以及多種性質不同的骨骼肌收縮功能異常(myotonia, myathenia gravis, and hypokalemic periodic paralysis)。我的研究重點是「離子通道之結構、功能、蛋白質平衡(protein homeostasis)」以及「離子通道疾病的致病機制(pathophysiology)」。

本實驗室目前正在進行的研究包含:

(1) 離子通道的生物物理、蛋白質化學、與細胞生物學研究 (Biophysics, protein chemistry, and cell biology of voltage-gated ion channels) 。

(2) 電位控制性離子通道與神經、肌肉、內分泌病變之相關性 (Channelopathy of voltage-gated ion channels)。

 

Publication List:

  1. Hsiao, C.-T., Tropea, T.F., Fu, S.-J., Bardakjian, T.M., Gonzalez-Alegre, P., Soong, B.-W., Tang, C.-Y., and Jeng, C.-J. (2021) Rare gain-of-function KCND3 variant associated with cerebellar ataxia, parkinsonism, cognitive dysfunction, and brain iron accumulation. Int. J. Mol. Sci. 22:8247.

  2. Fu, S.-J., Hu, M.-C., Hsiao, C.-T., Cheng, A.-T., Chen, T.-Y., Jeng, C.-J., and Tang, C.-Y. (2021) Regulation of ClC-2 chloride channel proteostasis by molecular chaperones: correction of leukodystrophy-associated defect. Int. J. Mol. Sci. 22:5859.

  3. Zanni, G., Hsiao, C.-T., Fu, S.-J., Tang, C.-Y., Capuano, A., Bosco, L., Graziola, F., Bellacchio, E., Servidei, S., Primiano, G., Soong, B.-W., and Jeng, C.-J. (2021) Novel KCND3 variant underlying nonprogressive congenital ataxia or SCA19/22 disrupt KV4.3 protein expression and K+ currents with variable effects on channel properties. Int. J. Mol. Sci. 22:4986.

  4. Fang, Y.-C., Fu, S.-J., Hsu, P.-H., Chang, P.-T., Huang, J.-J., Chiu, Y.-C., Liao, Y.-F., Jow, G.-M., Tang, C.-Y., and Jeng, C.-J. (2021) Identification of MKRN1 as a second E3 ligase for Eag1 potassium channels reveals regulation via differential degradation. J. Biol. Chem. (2021) 296:100484.

  5. Chiang, C.-S., Fu, S.-J., Hsu, C.-L., Jeng, C.-J., Tang, C.-Y., Huang, Y.-S., and Tang, S.-C. (2021) Neuronal exosomes secreted under oxygen-glucose deprivation/reperfusion presenting differentially expressed miRNAs and affecting neuronal survival and neurite outgrowth. NeuroMolecular Medicine (https:// doi: 10.1007/s12017-020-08641-z)

  6. Fu, S.-J., Hu, M.-C., Peng, Y.-J., Fang, H.-Y., Hsiao, C.-T., Chen, T.-Y., Jeng, C.-J., and Tang, C.-Y. (2020) CUL4-DDB1-CRBN E3 ubiquitin ligase regulates proteostasis of ClC-2 chloride channels: implication for aldosteronism and leukodystrophy. Cells 9:1332.

  7. Jeng, C.-J., Fu, S.-J., You, C.-Y., Peng, Y.-J., Hsiao, C.-T., Chen, T.-Y., and Tang, C.-Y. (2020) Defective gating and proteostasis of human ClC-1 chloride channel: molecular pathophysiology of myotonia congenita. Front. Neurol. 11:76. doi: 10.3389/fneur.2020.00076

  8. Hsiao, C.-T., Fu, S.-J., Liu, Y.-T., Lu,Y.-H., Zhong, C.-Y., Tang, C.-Y., Soong, B.-W., and Jeng, C.-J. (2019) Novel SCA19/22-associated KCND3 mutations disrupt human KV4.3 protein biosynthesis and channel gating. Human Mutation 40:2088-2107.

  9. Peng, Y.-J., Lee, Y.-C., Fu, S.-J., Chien, Y.-C., Liao, Y.-F., Chen, T.-Y., Jeng, C.-J., and Tang, C.-Y. (2018) FKBP8 enhances protein stability of the CLC-1 chloride channel at the plasma membrane. Int. J. Mol. Sci. 19:3783.

  10. Chi, C.-H., Tang, C.-Y., and Pan, C.-Y. (2017) Calmodulin modulates the Ca2+-dependent inactivation and expression level of bovine CaV2.2 expressed in HEK293T cells. IBRO Rep. 2:63-71.

  11. Fu, S.-J., Jeng, C.-J., Ma, C.-H., Peng, Y.-J., Lee, C.-M., Fang, Y.-C., Lee, Y.-C., Tang, S.-C., Hu, M.-C., and Tang, C.-Y. (2017) Ubiquitin ligase RNF138 promotes episodic ataxia type 2-associated aberrant degradation of human Cav2.1 (P/Q-type) calcium channels. J. Neurosci. 37:2485-2503.

  12. Hsu, P.-H., Ma, Y.-T., Fang, Y.-C., Huang, J.-J., Gan, Y.-L., Chang, P.-T., Jow, G.-M., Tang, C.-Y., and Jeng, C.-J. (2017) Cullin 7 mediates proteasomal and lysosomal degradations of rat Eag1 potassium channels. Sci. Rep. 7, 40825; doi: 10.1038/srep40825.

  13. Peng, Y.-J., Huang, J.-J., Wu, H.-H., Hsieh, H.-Y., Wu, C.-Y., Chen, S.-C., Chen, T.-Y., and Tang, C.-Y. (2016) Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β. Sci. Rep. 6, 32444; doi: 10.1038/srep32444.

  14. Chen, S.-H., Fu, S.-J., Huang, J.-J., and Tang, C.-Y. (2016) The episodic ataxia type 1 mutation I262T alters voltage-dependent gating and disrupts protein biosynthesis of human Kv1.1 potassium channels. Sci. Rep. 6, 19378; doi: 10.1038/srep19378.

  15. Chen, Y.-A., Peng, Y.-J., Hu, M.-C., Huang, J.-J., Chien, Y.-C., Wu, J.-T., Chen, T.-Y., and Tang, C.-Y. (2015) The cullin 4A/B-DDB1-cereblon E3 ubiquitin ligase complex mediates the degradation of CLC-1 chloride channels. Sci. Rep. 5, 10667; doi: 10.1038/srep10667.

  16. Liu, D.-C., Jow, G.-M. Chuang, C.-C., Peng, Y.-J., Hsu, P.-H., and Tang, C.-Y. (2013) Densin-180 is not a transmembrane protein. Cell Biochem. Biophysic. 67:773-783.

  17. Lee, T.-T., Zhang, X.-D. Chuang, C.-C., Chen, J.-J., Chen, Y.-A., Chen, S.-C., Chen, T.-Y., and Tang, C.-Y. (2013) Myotonia congenita mutation enhances the degradation of human CLC-1 chloride channels. PLoS One 8(2):e55930.

  18. Richman, D.P., Yu, Y., Lee, T.-T., Tseng, P.-Y., Yu, W.-P., Maselli, R.A., Tang, C.-Y. and Chen, T.-Y. (2012) Dominantly inherited myotonia congenita resulting from a mutation that increases open probability of the muscle chloride channel CLC-1. Neuromol Med 14: 328-337.

  19. Yi, Y.-H., Chang, Y.-S., Lin, C.-H., Lew, T.-S., Tang, C.-Y., Tseng, W.-L, Tseng, C.-P., and Lo, S.J. (2012) Integrin-mediated membrane blebbing is dependent on sodium-proton exchanger 1 and sodium-calcium exchanger 1 activity. J Biol Chem 287:10316-10324.
  20. Tang, C.-Y. and Chen, T.Y. (2011) Physiology and pathophysiology of CLC-1: mechanisms of a chloride channel disease, myotonia. J. Biomed. Biotech. 685328.
  21. Lai, Y.-P., Lin, C.-C., Liao, W.-L., Tang, C.-Y., Chen, S.-C. (2009) CD4+ T cell-derived IL-2 signals during early priming advances primary CD8+ T cell responses. PLoS ONE 4(11): e7766.
  22. Lin, H.-M., Liu, C.-Y., Jow, G.-M., and Tang, C.-Y. (2009) Toluene disrupts synaptogenesis in cultured hippocampal neurons. Toxicol Lett 184:90–96.
  23. Yi, Y.-H., Ho, P.-Y., Chen, T.-W., Lin, W.-J., Gukassyan, V., Tsai, T.-H., Wang, D.-W., Lew, T.-S., Tang, C.-Y., Lo, S. J., Chen, T.-Y., Kao, F.-J., and Lin, C.-H. (2009) Membrane targeting and coupling of NHE1/integrinαIIbβ3/NCX1 by lipid rafts following integrin-ligand interactions trigger Ca2+ oscillations. J Biol Chem 284:3855-3864.
  24. Kung, F.-L., Tsai, J.-L., Lee, C.-H., Lou, K.-L., Tang, C.-Y., Liou, H.-H., Lu, K.-L., Chen, Y.-H., Wang, W.-J, and Tsai, M.-C. (2008) Effects of sodium azide, barium ion, d-amphetamine and procaine on inward rectifying potassium channel 6.2 expressed in Xenopus oocytes. J Formos Med Assoc 107:600–608.
  25. Jeng, C.-J., Sun, M.-C., Chen, Y.-W., and Tang, C.-Y. (2008) Dominant-negative effects of episodic ataxia type 2 mutations involve disruption of membrane trafficking of human P/Q-type Ca2+ channels. J Cell Physiol 214:422-433.
  26. Tsai, M.-C., Tang, C.-Y., Chang, Y.-T.,Cheng, C.-L., Liao, J.-M., Lee, S.-D., Pan, S.-F., Chen, M.-J., Huang, P.-C., Lin, T.-B. (2006) Effects of selective unilateral dorsal root(s) rhizotomy on micturition reflex in anesthetized rats. Neurourology and Urodynamics. 25:820-827.
  27. Jeng, C.-J., Chen, Y.-T., Chen, Y.-W., and Tang, C.-Y. (2006) Dominant-negative Effects of human P/Q-type Ca2+ channel mutations associated with episodic ataxia type 2. Amer J Physiol-Cell Physiol 290:C1209-C1220.
  28. Yeh, J.-H., Jeng, C.-J., Chen, Y.-W., Lin, H.-M., Wu, Y.-S., and Tang, C.-Y. (2005) Selective enhancement of tonic inhibitionby increasing ambient GABA is insufficient to suppress excitotoxicity in hippocampal neurons. Biochemical and Biophysical Research Communications 338:1417-1425.
  29. Tang, C.-Y., Chen, Y.-W., Jow, G.-M., Chou, C.-J., and Jeng, C.-J. (2005) Beauvericin activates Ca2+-activated Cl- currents and induces cell deaths in Xenopus oocytes via influx of extracellular Ca2+. Chem Res Toxicol 18:825-833.
  30. Jeng, C.-J., Chang, C.-C., and Tang, C.-Y. (2005) Differential localization of rat Eag1 and Eag2 K+ channels in hippocampal neuron. Neuroreport 16:229-233.
  31. Stell, B.M., Brickley, S.G., Tang, C.-Y., Farrant, M., and Istvan Mody (2003) Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by δ subunit-containing GABAAreceptors. Proc. Natl. Acad. Sci. 100:14439-14444.
  32. Lin, C.F., Liao, J.M., Tsai, S.J., Chiang, P.Y., Ting, H., Tang C.-Y., Lou, K.L., Hsieh, L.C., Wang, D.W., and Lin, T.B. (2003) Depressor effect on blood pressure and flow elicited by electroacupuncture in normal subjects. Auton Neurosci. 107:60-4.
  33. Papazian, D.M., Silverman, W.R., Lin, M.C., Tiwari-Woodruff, S.K., and Tang, C.-Y. (2002) Structural organization of the voltage sensor in voltage-dependent potassium channels. Novartis Found Symp. 245:178-90
  34. Silverman, W.R., Tang, C.-Y., Mock, A. F., Huh, S., and Papazian, D.M. (2000) Mg2+ modulates voltage-dependent activation in ether-à-go-go potassium channels by Binding between transmembrane segments S2 and S3. J. Gen. Physiol. 116:663-677.
  35. Tang, C.-Y., Bezanilla, F., and Papazian, D.M. (2000) Extracellular Mg2+ modulates slow gating transitions and the opening of Drosophila ether-a-go-go K+ channels. J. Gen. Physiol. 115:319-337.
  36. Tang, C.-Y., Schulteis, C.T., Jimenez, R.M., and Papazian, D.M. (1998) Shaker and eag K+ channel subunits fail to co-assemble in Xenopus oocytes.
    Biophys. J. 75:1263-1270.
  37. Tang, C.-Y., and Papazian, D.M. (1997) Transfer of voltage independence from a rat olfactory channel to the Drosophila ether-a-go-go K+ channel. J. Gen. Physiol. 109:301-311.
  38. Schulteis, C.T., John, S.A., Huang, Y., Tang, C.-Y., and Papazian, D.M. (1995) Conserved cysteine residues in the shaker K+ channel are not linked by a disulfide bond. Biochemistry 34: 1725-1733.

The research directions of my lab include

  1. Biophysics and cell biology of ion channels.
  2. Molecular mechanisms of channelopathies.
  3. Physiology and cell biology of synaptic networks in cultured neurons.

Publication List:

  1. Hsiao, C.-T., Tropea, T.F., Fu, S.-J., Bardakjian, T.M., Gonzalez-Alegre, P., Soong, B.-W., Tang, C.-Y., and Jeng, C.-J. (2021) Rare gain-of-function KCND3 variant associated with cerebellar ataxia, parkinsonism, cognitive dysfunction, and brain iron accumulation. Int. J. Mol. Sci. 22:8247.

  2. Fu, S.-J., Hu, M.-C., Hsiao, C.-T., Cheng, A.-T., Chen, T.-Y., Jeng, C.-J., and Tang, C.-Y. (2021) Regulation of ClC-2 chloride channel proteostasis by molecular chaperones: correction of leukodystrophy-associated defect. Int. J. Mol. Sci. 22:5859.

  3. Zanni, G., Hsiao, C.-T., Fu, S.-J., Tang, C.-Y., Capuano, A., Bosco, L., Graziola, F., Bellacchio, E., Servidei, S., Primiano, G., Soong, B.-W., and Jeng, C.-J. (2021) Novel KCND3 variant underlying nonprogressive congenital ataxia or SCA19/22 disrupt KV4.3 protein expression and K+ currents with variable effects on channel properties. Int. J. Mol. Sci. 22:4986.

  4. Fang, Y.-C., Fu, S.-J., Hsu, P.-H., Chang, P.-T., Huang, J.-J., Chiu, Y.-C., Liao, Y.-F., Jow, G.-M., Tang, C.-Y., and Jeng, C.-J. (2021) Identification of MKRN1 as a second E3 ligase for Eag1 potassium channels reveals regulation via differential degradation. J. Biol. Chem. (2021) 296:100484.

  5. Chiang, C.-S., Fu, S.-J., Hsu, C.-L., Jeng, C.-J., Tang, C.-Y., Huang, Y.-S., and Tang, S.-C. (2021) Neuronal exosomes secreted under oxygen-glucose deprivation/reperfusion presenting differentially expressed miRNAs and affecting neuronal survival and neurite outgrowth. NeuroMolecular Medicine (https:// doi: 10.1007/s12017-020-08641-z)

  6. Fu, S.-J., Hu, M.-C., Peng, Y.-J., Fang, H.-Y., Hsiao, C.-T., Chen, T.-Y., Jeng, C.-J., and Tang, C.-Y. (2020) CUL4-DDB1-CRBN E3 ubiquitin ligase regulates proteostasis of ClC-2 chloride channels: implication for aldosteronism and leukodystrophy. Cells 9:1332.

  7. Jeng, C.-J., Fu, S.-J., You, C.-Y., Peng, Y.-J., Hsiao, C.-T., Chen, T.-Y., and Tang, C.-Y. (2020) Defective gating and proteostasis of human ClC-1 chloride channel: molecular pathophysiology of myotonia congenita. Front. Neurol. 11:76. doi: 10.3389/fneur.2020.00076

  8. Hsiao, C.-T., Fu, S.-J., Liu, Y.-T., Lu,Y.-H., Zhong, C.-Y., Tang, C.-Y., Soong, B.-W., and Jeng, C.-J. (2019) Novel SCA19/22-associated KCND3 mutations disrupt human KV4.3 protein biosynthesis and channel gating. Human Mutation 40:2088-2107.

  9. Peng, Y.-J., Lee, Y.-C., Fu, S.-J., Chien, Y.-C., Liao, Y.-F., Chen, T.-Y., Jeng, C.-J., and Tang, C.-Y. (2018) FKBP8 enhances protein stability of the CLC-1 chloride channel at the plasma membrane. Int. J. Mol. Sci. 19:3783.

  10. Chi, C.-H., Tang, C.-Y., and Pan, C.-Y. (2017) Calmodulin modulates the Ca2+-dependent inactivation and expression level of bovine CaV2.2 expressed in HEK293T cells. IBRO Rep. 2:63-71.

  11. Fu, S.-J., Jeng, C.-J., Ma, C.-H., Peng, Y.-J., Lee, C.-M., Fang, Y.-C., Lee, Y.-C., Tang, S.-C., Hu, M.-C., and Tang, C.-Y. (2017) Ubiquitin ligase RNF138 promotes episodic ataxia type 2-associated aberrant degradation of human Cav2.1 (P/Q-type) calcium channels. J. Neurosci. 37:2485-2503.

  12. Hsu, P.-H., Ma, Y.-T., Fang, Y.-C., Huang, J.-J., Gan, Y.-L., Chang, P.-T., Jow, G.-M., Tang, C.-Y., and Jeng, C.-J. (2017) Cullin 7 mediates proteasomal and lysosomal degradations of rat Eag1 potassium channels. Sci. Rep. 7, 40825; doi: 10.1038/srep40825.

  13. Peng, Y.-J., Huang, J.-J., Wu, H.-H., Hsieh, H.-Y., Wu, C.-Y., Chen, S.-C., Chen, T.-Y., and Tang, C.-Y. (2016) Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β. Sci. Rep. 6, 32444; doi: 10.1038/srep32444.

  14. Chen, S.-H., Fu, S.-J., Huang, J.-J., and Tang, C.-Y. (2016) The episodic ataxia type 1 mutation I262T alters voltage-dependent gating and disrupts protein biosynthesis of human Kv1.1 potassium channels. Sci. Rep. 6, 19378; doi: 10.1038/srep19378.

  15. Chen, Y.-A., Peng, Y.-J., Hu, M.-C., Huang, J.-J., Chien, Y.-C., Wu, J.-T., Chen, T.-Y., and Tang, C.-Y. (2015) The cullin 4A/B-DDB1-cereblon E3 ubiquitin ligase complex mediates the degradation of CLC-1 chloride channels. Sci. Rep. 5, 10667; doi: 10.1038/srep10667.

  16. Liu, D.-C., Jow, G.-M. Chuang, C.-C., Peng, Y.-J., Hsu, P.-H., and Tang, C.-Y. (2013) Densin-180 is not a transmembrane protein. Cell Biochem. Biophysic. 67:773-783.

  17. Lee, T.-T., Zhang, X.-D. Chuang, C.-C., Chen, J.-J., Chen, Y.-A., Chen, S.-C., Chen, T.-Y., and Tang, C.-Y. (2013) Myotonia congenita mutation enhances the degradation of human CLC-1 chloride channels. PLoS One 8(2):e55930.

  18. Richman, D.P., Yu, Y., Lee, T.-T., Tseng, P.-Y., Yu, W.-P., Maselli, R.A., Tang, C.-Y. and Chen, T.-Y. (2012) Dominantly inherited myotonia congenita resulting from a mutation that increases open probability of the muscle chloride channel CLC-1. Neuromol Med 14:328-337.

  19. Yi, Y.-H., Chang, Y.-S., Lin, C.-H., Lew, T.-S., Tang, C.-Y., Tseng, W.-L, Tseng, C.-P., and Lo, S.J. (2012) Integrin-mediated membrane blebbing is dependent on sodium-proton exchanger 1 and sodium-calcium exchanger 1 activity. J Biol Chem 287:10316-10324.

  20. Tang, C.-Y. and Chen, T.Y. (2011) Physiology and pathophysiology of CLC-1: mechanisms of a chloride channel disease, myotonia. J. Biomed. Biotech. 685328.
  21. Lai, Y.-P., Lin, C.-C., Liao, W.-L., Tang, C.-Y., Chen, S.-C. (2009) CD4+ T cell-derived IL-2 signals during early priming advances primary CD8+ T cell responses. PLoS ONE 4(11): e7766.
  22. Lin, H.-M., Liu, C.-Y., Jow, G.-M., and Tang, C.-Y. (2009) Toluene disrupts synaptogenesis in cultured hippocampal neurons. Toxicol Lett 184:90–96.
  23. Yi, Y.-H., Ho, P.-Y., Chen, T.-W., Lin, W.-J., Gukassyan, V., Tsai, T.-H., Wang, D.-W., Lew, T.-S., Tang, C.-Y., Lo, S. J., Chen, T.-Y., Kao, F.-J., and Lin, C.-H. (2009) Membrane targeting and coupling of NHE1/integrinαIIbβ3/NCX1 by lipid rafts following integrin-ligand interactions trigger Ca2+ oscillations. J Biol Chem 284:3855-3864.
  24. Kung, F.-L., Tsai, J.-L., Lee, C.-H., Lou, K.-L., Tang, C.-Y., Liou, H.-H., Lu, K.-L., Chen, Y.-H., Wang, W.-J, and Tsai, M.-C. (2008) Effects of sodium azide, barium ion, d-amphetamine and procaine on inward rectifying potassium channel 6.2 expressed in Xenopus oocytes. J Formos Med Assoc 107:600–608.
  25. Jeng, C.-J., Sun, M.-C., Chen, Y.-W., and Tang, C.-Y. (2008) Dominant-negative effects of episodic ataxia type 2 mutations involve disruption of membrane trafficking of human P/Q-type Ca2+ channels. J Cell Physiol 214:422-433.
  26. Tsai, M.-C., Tang, C.-Y., Chang, Y.-T.,Cheng, C.-L., Liao, J.-M., Lee, S.-D., Pan, S.-F., Chen, M.-J., Huang, P.-C., Lin, T.-B. (2006) Effects of selective unilateral dorsal root(s) rhizotomy on micturition reflex in anesthetized rats. Neurourology and Urodynamics. 25:820-827.
  27. Jeng, C.-J., Chen, Y.-T., Chen, Y.-W., and Tang, C.-Y. (2006) Dominant-negative Effects of human P/Q-type Ca2+ channel mutations associated with episodic ataxia type 2. Amer J Physiol-Cell Physiol 290:C1209-C1220.
  28. Yeh, J.-H., Jeng, C.-J., Chen, Y.-W., Lin, H.-M., Wu, Y.-S., and Tang, C.-Y. (2005) Selective enhancement of tonic inhibitionby increasing ambient GABA is insufficient to suppress excitotoxicity in hippocampal neurons. Biochemical and Biophysical Research Communications 338:1417-1425.
  29. Tang, C.-Y., Chen, Y.-W., Jow, G.-M., Chou, C.-J., and Jeng, C.-J. (2005) Beauvericin activates Ca2+-activated Cl- currents and induces cell deaths in Xenopus oocytes via influx of extracellular Ca2+. Chem Res Toxicol 18:825-833.
  30. Jeng, C.-J., Chang, C.-C., and Tang, C.-Y. (2005) Differential localization of rat Eag1 and Eag2 K+ channels in hippocampal neuron. Neuroreport 16:229-233.
  31. Stell, B.M., Brickley, S.G., Tang, C.-Y., Farrant, M., and Istvan Mody (2003) Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by δ subunit-containing GABAAreceptors. Proc. Natl. Acad. Sci. 100:14439-14444.
  32. Lin, C.F., Liao, J.M., Tsai, S.J., Chiang, P.Y., Ting, H., Tang C.-Y., Lou, K.L., Hsieh, L.C., Wang, D.W., and Lin, T.B. (2003) Depressor effect on blood pressure and flow elicited by electroacupuncture in normal subjects. Auton Neurosci. 107:60-4.
  33. Papazian, D.M., Silverman, W.R., Lin, M.C., Tiwari-Woodruff, S.K., and Tang, C.-Y. (2002) Structural organization of the voltage sensor in voltage-dependent potassium channels. Novartis Found Symp. 245:178-90
  34. Silverman, W.R., Tang, C.-Y., Mock, A. F., Huh, S., and Papazian, D.M. (2000) Mg2+ modulates voltage-dependent activation in ether-à-go-go potassium channels by Binding between transmembrane segments S2 and S3. J. Gen. Physiol. 116:663-677.
  35. Tang, C.-Y., Bezanilla, F., and Papazian, D.M. (2000) Extracellular Mg2+ modulates slow gating transitions and the opening of Drosophila ether-a-go-go K+ channels. J. Gen. Physiol. 115:319-337.
  36. Tang, C.-Y., Schulteis, C.T., Jimenez, R.M., and Papazian, D.M. (1998) Shaker and eag K+ channel subunits fail to co-assemble in Xenopus oocytes.
    Biophys. J. 75:1263-1270.
  37. Tang, C.-Y., and Papazian, D.M. (1997) Transfer of voltage independence from a rat olfactory channel to the Drosophila ether-a-go-go K+ channel. J. Gen. Physiol. 109:301-311.
  38. Schulteis, C.T., John, S.A., Huang, Y., Tang, C.-Y., and Papazian, D.M. (1995) Conserved cysteine residues in the shaker K+ channel are not linked by a disulfide bond. Biochemistry 34: 1725-1733.

博士班學生

游佳穎
鄭楷民

碩士班學生

林欣叡
蔡佩臻
藍渝淇

博士後研究員

傅斯如

歷史成員

博士班畢業生 (畢業年份)

許博皓 (2015)

傅斯如 (2017)

蕭丞宗 (2020)

碩士班畢業生 (畢業年份)

陳裕廷 (2004)

張綺真 (2004)

孫閔貞 (2005)

陳怡文 (2006)

林惠敏 (2006)

翁于涵 (2007)

李婷婷 (2009)

吳佳穎 (2009)

劉岱祺 (2010)

胡瑞香 (2011)

陳思涵 (2011)

劉政昕 (2011)

傅斯如 (2011)

李啟銘 (2012)

林廷峯 (2013)

陳怡安 (2014)

彭怡錚 (2014)

黃敬家 (2015)

方欣妤 (2015)

簡韻珈 (2015)

李宜靜 (2017)

陳子元 (2018)

羅   祥 (2018)

鍾蕎聿 (2018)