成員簡介

張哲逢副教授

張哲逢副教授
  • 張哲逢

  • 職  稱:副教授
  • 學  歷:國防醫學院 生命科學研究所 博士
  • 專  長:神經免疫學暨腦血管疾病
  • 聯絡電話:02-23123456 ext.288238
  • E-mail:chefengchang@ntu.edu.tw

Our Research Interests- The Beauty of Neuroimmunology

Dr. Chang's research is driven by the desire to develop effective medical therapy for intracerebral hemorrhage (ICH). He seeks to better understand the interaction between immune cells and/or CNS cells in the context of diseases. The Chang lab establishes and uses innovative neuroimmunological and computational tools to study the characteristics and reaction of specific immune cell population in the injured brain. They have also established in vivo, in vitro, and ex vivo platforms to mimic different types of ICH injury. Even better than treating disease itself is to prevent disease from occurring in the first place. Dr. Chang’s intent, therefore, is to understand how environmental factors and dietary habits influence innate immune cells for cerebrovascular disease prevention. He believes in and practice providing a stimulating and collaborative environment that promotes the free exchange of ideas and encourages creative scientificthinking.

Our Team- A Collaborative Group of Innovative, Passionate, and Creative Students

The Physiology 1038 is committed to training the next generation biomedical scientists who are genuinely interested in research in the fields of immunology, neurobiology, and cerebrovascular diseases. The goal of a Master training entails gaining basic knowledge on intracerebral hemorrhage and understanding the molecular basis of neuro-immune interactions as well as subsequently completing a small project that amounts to work equivalent of a short report/communication article by the time a Master’s degree is awarded. The goal of a PhD trainee is to answer at least one knowledge gap that is relevant to the pathophysiological mechanism and therapeutic strategy in the developmental or adult ICH brain. The research findings should be expected to lead to 1-2 peer-reviewed full articles and a complete story for dissertation. By the time a PhD title is awarded, the trainees should have the ability to independently conduct research project and troubleshoot when encountering (technical/intellectual) bottlenecks, and have in-depth knowledge in the area of topics where one’s thesis focused.

2022.08-
Associate Professor, Graduate Institute of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan

2018.08-2022.07
Assistant Professor, Graduate Institute of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan

2017.08-2018.07
Associate Research Scientist, Department of Neurology, Yale University, School of Medicine, New Haven, CT, USA

2015.04-2017.07
Postdoctoral Fellow, Department of Neurology, Yale University, School of Medicine, New Haven, CT, USA

2013.01-2015.04
Postdoctoral Fellow, Department of Anesthesiology/Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA

2023 Emerging Young Scholar, Cross-Generation Young Scholars Program (國科會2030跨世代年輕學者-新秀學者), National Science and Technology Council, Taiwan

2023 Chin-Hsin Medical Award (財團法人青杏文教基金會青杏醫學獎), National Taiwan University College of Medicine, Taipei, Taiwan

2023 Annual mentorship award (111學年度台大醫學系優良導師), School of Medicine, National Taiwan University College of Medicine, Taipei, Taiwan

2022 Annual best basic science teacher award (臺大醫學院北美校友基金會最佳基礎教師獎), National Taiwan University College of Medicine, Taipei, Taiwan

2022 Annual teaching award (110學年度臺灣大學專任教師教學優良獎), National Taiwan University, Taipei, Taiwan

2022 Annual mentorship award (110學年度台大醫學系優良導師), School of Medicine, National Taiwan University College of Medicine, Taipei, Taiwan

2021 The Young Scholars' Creativity Award (財團法人傑出人才基金會年輕學者創新獎), Foundation for the Advancement of Outstanding Scholarship, Taipei, Taiwan 

2021 Annual teaching award (109學年度臺灣大學專任教師教學優良獎), National Taiwan University, Taipei, Taiwan 

2021 Annual mentorship award (109學年度台大醫學系優良導師), School of Medicine, National Taiwan University College of Medicine, Taipei, Taiwan 

2020 MOST Excellent Junior Research Investigator Grant (科技部優秀年輕學者研究計畫), Ministry of Science and Technology, Taiwan 

2019 Outstanding alumni award, Graduate Institute of Physiology, National Defense Medical Center, Taipei, Taiwan

2018 科技部補助延攬特殊優秀人才, Ministry of Science and Technology, Taiwan

2017 Travel grant, the 6th World Intracranial Hemorrhage Conference, Baltimore, MD, USA

2015 Postdoctoral fellowship (科技部補助赴國外從事博士後研究), Ministry of Science and Technology, Taiwan

2013 1st Place award, the 15th Annual ACCM Research Day, Johns Hopkins University, School of Medicine, Baltimore, MD, USA

2012 Excellent soldier award (陸軍獎狀), Army General Headquarters, Republic of China Army, Taiwan

2011 Award of excellent Ph.D. thesis sponsored by Dr. Chien-Tien Hsu (徐千田優秀論文獎), the 19th Symposium on Recent Advances in Cellular and Molecular Biology, Kaohsiung, Taiwan

2011 Young investigators travel grant, the 13th International TNF Conference, Awaji, Japan

2011 Outstanding students conference travel grant, Foundation for the Advancement of Outstanding Scholarship (財團法人傑出人才發展基金會優秀學生出國開會補助), Taipei, Taiwan

2011 Ph.D. student thesis research award (博士班研究生優秀研究論文獎), the 11th Student Thesis Workshop of the Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan

2010 Honorable Mentions (研究生論文研討會海報比賽), the 10th Student Thesis Workshop of the Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan

(*corresponding author)

Lin TY, Jiang D, Chen WR, Lin JS, Zhang XY, Chen CH, Hsu, CL, Lai LC, Chen PH, Yang KC, Sansing LH, Chang CF*. Trained immunity induced by high salt diet impedes stroke recovery. EMBO Reports. 2023; e57164.

Tsai HH, Hsieh YC, Lin JS, Kuo ZT, Ho CY, Chen CH, Chang CF*. Functional investigation of meningeal lymphatic system in experimental intracerebral hemorrhage. Stroke. 2022; 53:987-998.

Tsai HH, Chen YF, Yen RF, Lo YL, Yang KC, Jeng JS, Tsai LK, Chang CF*. Plasma soluble TREM2 is associated with white matter lesions independent of amyloid and tau. Brain. 2021; 11: 3371-3380. (Highlighted in Editor's Choice)

(Scientific commentary by Elena Rodriguez-Vieitez and Nicholas J Ashton. Plasma sTREM2: a potential marker of cerebrovascular injury in neurodegenerative disorders. Brain. 2021; 11: 3283-3285.)

Chang CF, Goods BA, Askenase MH, Beatty HE, Osherov A, Delong J, Hammond MD, Massey J, Landreneau MJ, Love JC, Sansing LH*. Divergent functions of tissue-resident and blood-derived macrophages in the hemorrhagic brain. Stroke. 2021; 52: 1798-1808.

Chang CF, Massey J, Osherov A, Costa L, Sansing LH*. Bexarotene enhances macrophage erythrophagocytosis and hematoma clearance in experimental intracerebral hemorrhage. Stroke. 2020; 51: 612-618.

(Chang CF and Sansing LH*. Response by Chang and Sansing to Letter Regarding Article, “Bexarotene Enhances Macrophage Erythrophagocytosis and Hematoma Clearance in Experimental Intracerebral Hemorrhage". Stroke. 2020; 51: e88.)

Lee HF, Chen CH, Chang CF*. A preclinical controlled cortical impact model for traumatic hemorrhage contusion and neuroinflammation. JoVE. 2020; e61393.

Lee HF, Lin JS, Chang CF*. Acute kahweol treatment attenuates traumatic brain injury neuroinflammation and functional deficits. Nutrients. 2019; 11: 2301.

Chang CF, Goods BA, Askenase MH, Hammond MD, Renfroe SC, Steinschneider AF, Landreneau MJ, Ai Y, Beatty H, Costa L, Mack M, Sheth KN, Greer DM, Huttner A, Coman D, Hyder F, Ghosh S, Rothlin CV, Love JC, Sansing LH*. Efferocytosis of erythrocytes modulates macrophages towards recovery after intracerebral hemorrhage. Journal of Clinical Investigation. 2018; 128: 607-624. (Highlighted in JCI This Month)

Taylor RA, Chang CF, Goods BA, Hammond MD, Grory BM, Ai Y, Steinschneider AF, Renfroe SC, Askenase MH, McCullough LD, Kasner SE, Mullen MT, Hafler DA, Love JC, and Sansing LH*. TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage. Journal of Clinical Investigation. 2017; 127: 280–292.

Chang CF, Wan J, Li Q, Renfroe SC, Heller NM*, and Wang J. Alternative activation-skewed microglia/macrophages promote hematoma resolution after intracerebral hemorrhage. Neurobiology of Disease. 2017; 103: 54-69.

Wang M, Hong X, Chang CF (equal contribution first-author), Li Q, Ma B, Zhang H, Xiang S, Heo HY, Zhang Y, Lee DH, Jiang S, Leigh R, Koehler RC, van Zijl PC, Wang J*, and Zhou J*. Simultaneous detection and separation of hyperacute intracerebral hemorrhage and cerebral ischemia using amide proton transfer MRI. Magnetic Resonance in Medicine. 2015; 74: 42-50.

Zhao X, Wu T*, Chang CF (equal contribution first-author), Wu H, Han X, Li Q, Gao Y, Li Q, Hou Z, Maruyama T, Zhang J, Wang J*. Toxic role of prostaglandin E2 receptor EP1 after intracerebral hemorrhage in mice. Brain, Behavior, and Immunity. 2015; 46: 293–310.

Chang CF, Cai L, Wang J*. Translational intracerebral hemorrhage: a need for transparent descriptions of fresh tissue sampling and preclinical model quality. Translational Stroke Research. 2015; 6:384-389.

Chang CF, Suzy C, Wang J*. (-)-Epicatechin protects hemorrhagic brain via synergistic Nrf2 pathways. Annals of Clinical and Translational Neurology. 2014; 4:258-271.

Zhu W, Gao Y, Chang CF, Wan JR, Zhu SS, Wang J*. Mouse models of intracerebral hemorrhage in ventricle, cortex, and hippocampus by injections of autologous blood or collagenase. PLoS One. 2014; 9(5):e97423.

Chang CF, Chen SF, Lee TS, Lee HF, Chen SF*, Shyue SK*. Caveolin-1 deletion reduces early brain injury after experimental intracerebral hemorrhage. American Journal of Pathology. 2011; 178:1749-1761.

Shyue SK, Chen SF, Wu CH, Chang CF. Caveolin-1 antibody for use in treating brain inflammation and injury and improving functional recovery. US patent 11,097,134 B2. Aug. 24, 2021

Che-Feng Chang, PhD
Associate Professor
Graduate Institute of Physiology
National Taiwan University College of Medicine
Taipei, Taiwan

TEL: +886-2-23123456 ext.288238
FAX: +886-2-23964350
E-mail: chefengchang@ntu.edu.tw

Lab website: https://sites.google.com/view/physiologychanglab1038/home

Dr. Chang's research is driven by the desire to develop effective medical therapy for intracerebral hemorrhage (ICH). He seeks to better understand the interaction between immune cells and/or CNS cells in the context of diseases. The Chang lab establishes and uses innovative neuroimmunological and computational tools to study the characteristics and reaction of specific immune cell population in the injured brain. They have also established in vivo, in vitro, and ex vivo platforms to mimic different types of ICH injury.

Even better than treating disease itself is to prevent disease from occurring in the first place. Dr. Chang’s intent, therefore, is to understand how environmental factors and dietary habits influence innate immune cells for cerebrovascular disease prevention.

Dr. Chang is committed to training the next generation of biomedical scientists including MS, PhD, MD-PhD, and postdoctoral trainees. He believes in and practice providing a stimulating and collaborative environment that promotes the free exchange of ideas and encourages creative scientificthinking.

ACADEMIC EXPERIENCE

2022.08-
Associate Professor, Graduate Institute of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan

2018.08-2022.07
Assistant Professor, Graduate Institute of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan

2017.08-2018.07
Associate Research Scientist/Junior Research Faculty, Department of Neurology, Yale University, School of Medicine, New Haven, CT, USA

2015.04-2017.07
Postdoctoral Fellow, Department of Neurology, Yale University, School of Medicine, New Haven, CT, USA

2013.01-2015.04
Postdoctoral Fellow, Department of Anesthesiology/Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA


HONORS AND AWARDS

2023 Emerging Young Scholar, Cross-Generation Young Scholars Program, National Science and Technology Council, Taiwan

2023 Chin-Hsin Medical Award, National Taiwan University College of Medicine, Taipei, Taiwan

2023 Annual mentorship award, School of Medicine, National Taiwan University College of Medicine, Taipei, Taiwan

2022 Annual best basic science teacher award, National Taiwan University College of Medicine, Taipei, Taiwan 

2022 Annual teaching award, National Taiwan University, Taipei, Taiwan 

2022 Annual mentorship award, School of Medicine, National Taiwan University College of Medicine, Taipei, Taiwan 

2021 The Young Scholars' Creativity Award, Foundation for the Advancement of Outstanding Scholarship, Taipei, Taiwan

2021 Annual teaching award, National Taiwan University, Taipei, Taiwan 

2021 Annual mentorship award, School of Medicine, National Taiwan University College of Medicine, Taipei, Taiwan

2020 Excellent Junior Research Investigator Grant, Ministry of Science and Technology, Taiwan

2019 Outstanding alumni award, Graduate Institute of Physiology, National Defense Medical Center, Taipei, Taiwan

2018 Outstanding Talents Recruitment Grant, Ministry of Science and Technology, Taiwan

2017 Travel grant, the 6th World Intracranial Hemorrhage Conference, Baltimore, MD, USA

2015 Postdoctoral fellowship, Ministry of Science and Technology, Taiwan

2013 1st Place award, the 15th Annual ACCM Research Day, Johns Hopkins University, School of Medicine, Baltimore, MD, USA

2012 Excellent soldier award, Army General Headquarters, Republic of China Army, Taiwan

2011 Award of excellent Ph.D. thesis sponsored by Dr. Chien-Tien Hsu, the 19th Symposium on Recent Advances in Cellular and Molecular Biology, Kaohsiung, Taiwan

2011 Young investigators travel grant, the 13th International TNF Conference, Awaji, Japan

2011 Outstanding students conference travel grant, Foundation for the Advancement of Outstanding Scholarship, Taipei, Taiwan

2011 Ph.D. student thesis research award, the 11th Student Thesis Workshop of the Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan

2010 Honorable Mentions, the 10th Student Thesis Workshop of the Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan


PUBLICATIONS (*corresponding author)

  1. Lin TY, Jiang D, Chen WR, Lin JS, Zhang XY, Chen CH, Hsu, CL, Lai LC, Chen PH, Yang KC, Sansing LH, Chang CF*. Trained immunity induced by high salt diet impedes stroke recovery. EMBO Reports. 2023; e57164.
  2. Tsai HH, Hsieh YC, Lin JS, Kuo ZT, Ho CY, Chen CH, Chang CF*. Functional investigation of meningeal lymphatic system in experimental intracerebral hemorrhage. Stroke. 2022; 53:987-998.
  3. Tsai HH, Chen YF, Yen RF, Lo YL, Yang KC, Jeng JS, Tsai LK, Chang CF*. Plasma soluble TREM2 is associated with white matter lesions independent of amyloid and tau. Brain. 2021; doi.org/10.1093/brain/awab332. (Highlighted in Editor's Choice) (Scientific commentary by Elena Rodriguez-Vieitez and Nicholas J Ashton. Plasma sTREM2: a potential marker of cerebrovascular injury in neurodegenerative disorders. Brain. 2021; doi.org/10.1093/brain/awab399.)
  4. Chang CF, Goods BA, Askenase MH, Beatty HE, Osherov A, Delong J, Hammond MD, Massey J, Landreneau MJ, Love JC, Sansing LH*. Divergent functions of tissue-resident and blood-derived macrophages in the hemorrhagic brain. Stroke. 2021; 52:1798-1808.
  5. Chang CF, Massey J, Osherov A, Costa L, Sansing LH*. Bexarotene enhances macrophage erythrophagocytosis and hematoma clearance in experimental intracerebral hemorrhage. Stroke. 2020; 51:612-618.
  6. Lee HF, Chen CH, Chang CF*. A preclinical controlled cortical impact model for traumatic hemorrhage contusion and neuroinflammation. JoVE. 2020; e61393.
  7. Lee HF, Lin JS, Chang CF*. Acute kahweol treatment attenuates traumatic brain injury neuroinflammation and functional deficits. Nutrients. 2019; 11: 2301.
  8. Chang CF, Goods BA, Askenase MH, Hammond MD, Renfroe SC, Steinschneider AF, Landreneau MJ, Ai Y, Beatty H, Costa L, Mack M, Sheth KN, Greer DM, Huttner A, Coman D, Hyder F, Ghosh S, Rothlin CV, Love JC, Sansing LH*. Efferocytosis of erythrocytes modulates macrophages towards recovery after intracerebral hemorrhage. Journal of Clinical Investigation. 2018; 128: 607-624. (Highlighted in JCI This Month)
  9. Taylor RA, Chang CF, Goods BA, Hammond MD, Grory BM, Ai Y, Steinschneider AF, Renfroe SC, Askenase MH, McCullough LD, Kasner SE, Mullen MT, Hafler DA, Love JC, and Sansing LH*. TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage. Journal of Clinical Investigation. 2017; 127: 280–292.
  10. Chang CF, Wan J, Li Q, Renfroe SC, Heller NM*, and Wang J. Alternative activation-skewed microglia/macrophages promote hematoma resolution after intracerebral hemorrhage. Neurobiology of Disease. 2017; 103: 54-69.
  11. Wang M, Hong X, Chang CF (equal contribution first-author), Li Q, Ma B, Zhang H, Xiang S, Heo HY, Zhang Y, Lee DH, Jiang S, Leigh R, Koehler RC, van Zijl PC, Wang J*, and Zhou J*. Simultaneous detection and separation of hyperacute intracerebral hemorrhage and cerebral ischemia using amide proton transfer MRI. Magnetic Resonance in Medicine. 2015; 74: 42-50.
  12. Zhao X, Wu T*, Chang CF (equal contribution first-author), Wu H, Han X, Li Q, Gao Y, Li Q, Hou Z, Maruyama T, Zhang J, Wang J*. Toxic role of prostaglandin E2 receptor EP1 after intracerebral hemorrhage in mice. Brain, Behavior, and Immunity. 2015; 46: 293–310.
  13. Chang CF, Cai L, Wang J*. Translational intracerebral hemorrhage: a need for transparent descriptions of fresh tissue sampling and preclinical model quality. Translational Stroke Research. 2015; 6:384-389.
  14. Chang CF, Suzy C, Wang J*. (-)-Epicatechin protects hemorrhagic brain via synergistic Nrf2 pathways. Annals of Clinical and Translational Neurology. 2014; 4:258-271.
  15. Zhu W, Gao Y, Chang CF, Wan JR, Zhu SS, Wang J*. Mouse models of intracerebral hemorrhage in ventricle, cortex, and hippocampus by injections of autologous blood or collagenase. PLoS One. 2014; 9(5):e97423.
  16. Chang CF, Chen SF, Lee TS, Lee HF, Chen SF*, Shyue SK*. Caveolin-1 deletion reduces early brain injury after experimental intracerebral hemorrhage. American Journal of Pathology. 2011; 178:1749-1761.

博士班學生

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碩士班學生

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